Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice

The DNA damage response (DDR) is a highly orchestrated process but how double-strand DNA breaks (DSBs) are initially recognized is unclear. Here, we show that polymerized SIRT6 deacetylase recognizes DSBs and potentiates the DDR in human and mouse cells. First, SIRT1 deacetylates SIRT6 at residue K3...

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Detalles Bibliográficos
Autores principales: Meng, Fanbiao, Qian, Minxian, Peng, Bin, Peng, Linyuan, Wang, Xiaohui, Zheng, Kang, Liu, Zuojun, Tang, Xiaolong, Zhang, Shuju, Sun, Shimin, Cao, Xinyue, Pang, Qiuxiang, Zhao, Bosheng, Ma, Wenbin, Songyang, Zhou, Xu, Bo, Zhu, Wei-Guo, Xu, Xingzhi, Liu, Baohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324161/
https://www.ncbi.nlm.nih.gov/pubmed/32538779
http://dx.doi.org/10.7554/eLife.55828

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