HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis

Cancer cells can develop a strong addiction to discrete molecular regulators, which control the aberrant gene expression programs that drive and maintain the cancer phenotype. Here, we report the identification of the RNA-binding protein HuR/ELAVL1 as a central oncogenic driver for malignant periphe...

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Detalles Bibliográficos
Autores principales: Palomo-Irigoyen, Marta, Pérez-Andrés, Encarni, Iruarrizaga-Lejarreta, Marta, Barreira-Manrique, Adrián, Tamayo-Caro, Miguel, Vila-Vecilla, Laura, Moreno-Cugnon, Leire, Beitia, Nagore, Medrano, Daniela, Fernández-Ramos, David, Lozano, Juan José, Okawa, Satoshi, Lavín, José L., Martín-Martín, Natalia, Sutherland, James D., de Juan, Virginia Guitiérez, Gonzalez-Lopez, Monika, Macías-Cámara, Nuria, Mosén-Ansorena, David, Laraba, Liyam, Hanemann, C. Oliver, Ercolano, Emanuela, Parkinson, David B., Schultz, Christopher W., Araúzo-Bravo, Marcos J., Ascensión, Alex M., Gerovska, Daniela, Iribar, Haizea, Izeta, Ander, Pytel, Peter, Krastel, Philipp, Provenzani, Alessandro, Seneci, Pierfausto, Carrasco, Ruben D., Del Sol, Antonio, Martinez-Chantar, María Luz, Barrio, Rosa, Serra, Eduard, Lazaro, Conxi, Flanagan, Adrienne M., Gorospe, Myriam, Ratner, Nancy, Aransay, Ana M., Carracedo, Arkaitz, Varela-Rey, Marta, Woodhoo, Ashwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324187/
https://www.ncbi.nlm.nih.gov/pubmed/32315290
http://dx.doi.org/10.1172/JCI130379

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