A novel pipeline of 2-(benzenesulfonamide)-N-(4-hydroxyphenyl) acetamide analgesics that lack hepatotoxicity and retain antipyresis

Although acetaminophen (ApAP) is one of the most commonly used medicines worldwide, hepatotoxicity is a risk with overdose or in patients with compromised liver function. ApAP overdose is the most common cause of acute fulminant hepatic failure. Oxidation of ApAP to N-acetyl-p-benzoquinone imine (NA...

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Detalles Bibliográficos
Autores principales: Bazan, Hernan A., Bhattacharjee, Surjyadipta, Burgos, Carolina, Recio, Javier, Abet, Valentina, Pahng, Amanda R., Jun, Bokkyoo, Heap, Jessica, Ledet, Alexander J., Gordon, William C., Edwards, Scott, Paul, Dennis, Alvarez-Builla, Julio, Bazan, Nicolas G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Masson SAS. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324353/
https://www.ncbi.nlm.nih.gov/pubmed/32629335
http://dx.doi.org/10.1016/j.ejmech.2020.112600

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