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Spatial Patterns of Gene Expression in Bacterial Genomes
Gene expression in bacteria is a remarkably controlled and intricate process impacted by many factors. One such factor is the genomic position of a gene within a bacterial genome. Genes located near the origin of replication generally have a higher expression level, increased dosage, and are often m...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324424/ https://www.ncbi.nlm.nih.gov/pubmed/32506154 http://dx.doi.org/10.1007/s00239-020-09951-3 |
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author | Lato, Daniella F. Golding, G. Brian |
author_facet | Lato, Daniella F. Golding, G. Brian |
author_sort | Lato, Daniella F. |
collection | PubMed |
description | Gene expression in bacteria is a remarkably controlled and intricate process impacted by many factors. One such factor is the genomic position of a gene within a bacterial genome. Genes located near the origin of replication generally have a higher expression level, increased dosage, and are often more conserved than genes located farther from the origin of replication. The majority of the studies involved with these findings have only noted this phenomenon in a single gene or cluster of genes that was re-located to pre-determined positions within a bacterial genome. In this work, we look at the overall expression levels from eleven bacterial data sets from Escherichia coli, Bacillus subtilis, Streptomyces, and Sinorhizobium meliloti. We have confirmed that gene expression tends to decrease when moving away from the origin of replication in majority of the replicons analysed in this study. This study sheds light on the impact of genomic location on molecular trends such as gene expression and highlights the importance of accounting for spatial trends in bacterial molecular analysis. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00239-020-09951-3) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-7324424 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-73244242020-07-07 Spatial Patterns of Gene Expression in Bacterial Genomes Lato, Daniella F. Golding, G. Brian J Mol Evol Original Article Gene expression in bacteria is a remarkably controlled and intricate process impacted by many factors. One such factor is the genomic position of a gene within a bacterial genome. Genes located near the origin of replication generally have a higher expression level, increased dosage, and are often more conserved than genes located farther from the origin of replication. The majority of the studies involved with these findings have only noted this phenomenon in a single gene or cluster of genes that was re-located to pre-determined positions within a bacterial genome. In this work, we look at the overall expression levels from eleven bacterial data sets from Escherichia coli, Bacillus subtilis, Streptomyces, and Sinorhizobium meliloti. We have confirmed that gene expression tends to decrease when moving away from the origin of replication in majority of the replicons analysed in this study. This study sheds light on the impact of genomic location on molecular trends such as gene expression and highlights the importance of accounting for spatial trends in bacterial molecular analysis. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00239-020-09951-3) contains supplementary material, which is available to authorized users. Springer US 2020-06-06 2020 /pmc/articles/PMC7324424/ /pubmed/32506154 http://dx.doi.org/10.1007/s00239-020-09951-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Original Article Lato, Daniella F. Golding, G. Brian Spatial Patterns of Gene Expression in Bacterial Genomes |
title | Spatial Patterns of Gene Expression in Bacterial Genomes |
title_full | Spatial Patterns of Gene Expression in Bacterial Genomes |
title_fullStr | Spatial Patterns of Gene Expression in Bacterial Genomes |
title_full_unstemmed | Spatial Patterns of Gene Expression in Bacterial Genomes |
title_short | Spatial Patterns of Gene Expression in Bacterial Genomes |
title_sort | spatial patterns of gene expression in bacterial genomes |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324424/ https://www.ncbi.nlm.nih.gov/pubmed/32506154 http://dx.doi.org/10.1007/s00239-020-09951-3 |
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