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Expression of H3K4me3 and H3K9ac in breast cancer

PURPOSE: Breast cancer is the leading cause of cancer death in females. Histone modifications have been shown to have an influence on the gene expression. This study focusses on the histone modifications H3K9ac and H3K4me3 in breast cancer and their impact on survival METHODS: H3K4me3 and H3K9ac exp...

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Autores principales: Berger, Luisa, Kolben, Thomas, Meister, Sarah, Kolben, Theresa M., Schmoeckel, Elisa, Mayr, Doris, Mahner, Sven, Jeschke, Udo, Ditsch, Nina, Beyer, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324433/
https://www.ncbi.nlm.nih.gov/pubmed/32468423
http://dx.doi.org/10.1007/s00432-020-03265-z
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author Berger, Luisa
Kolben, Thomas
Meister, Sarah
Kolben, Theresa M.
Schmoeckel, Elisa
Mayr, Doris
Mahner, Sven
Jeschke, Udo
Ditsch, Nina
Beyer, Susanne
author_facet Berger, Luisa
Kolben, Thomas
Meister, Sarah
Kolben, Theresa M.
Schmoeckel, Elisa
Mayr, Doris
Mahner, Sven
Jeschke, Udo
Ditsch, Nina
Beyer, Susanne
author_sort Berger, Luisa
collection PubMed
description PURPOSE: Breast cancer is the leading cause of cancer death in females. Histone modifications have been shown to have an influence on the gene expression. This study focusses on the histone modifications H3K9ac and H3K4me3 in breast cancer and their impact on survival METHODS: H3K4me3 and H3K9ac expression was immunohistochemically examined in 235 tissue samples. RESULTS: Positive estrogen receptor status was correlated with a higher IRS of the nuclear (p = 0.033), and of the cytoplasmic H3K4me3 staining (p = 0.009). H3K9ac intensity was associated to the Her2 status (p = 0.045) and to poor prognosis in cells with positive Ki67 status (p = 0.013). A high intensity of nuclear H3K4me3 staining was found to be correlated with a lower 10-year-survival (p = 0.026) and with lower breast cancer-specific survival (p = 0.004). High percentage score (> 190) of H3K9ac expression was correlated to worse breast cancer-specific survival (p = 0.005). Shorter progression-free survival was found in patients with nuclear (p = 0.013) and cytoplasmic H3K4me3expression (p = 0.024) and H3K9ac expression (p = 0.023). CONCLUSION: This analysis provides new evidence of histone modifications in breast cancer. High H3K4me3 and H3K9ac expression was correlated with survival rates. Further investigation of histone modifications in breast cancer could lead to a more profound understanding of the molecular mechanisms of cancer development and could result in new therapeutic strategies.
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spelling pubmed-73244332020-07-07 Expression of H3K4me3 and H3K9ac in breast cancer Berger, Luisa Kolben, Thomas Meister, Sarah Kolben, Theresa M. Schmoeckel, Elisa Mayr, Doris Mahner, Sven Jeschke, Udo Ditsch, Nina Beyer, Susanne J Cancer Res Clin Oncol Original Article – Cancer Research PURPOSE: Breast cancer is the leading cause of cancer death in females. Histone modifications have been shown to have an influence on the gene expression. This study focusses on the histone modifications H3K9ac and H3K4me3 in breast cancer and their impact on survival METHODS: H3K4me3 and H3K9ac expression was immunohistochemically examined in 235 tissue samples. RESULTS: Positive estrogen receptor status was correlated with a higher IRS of the nuclear (p = 0.033), and of the cytoplasmic H3K4me3 staining (p = 0.009). H3K9ac intensity was associated to the Her2 status (p = 0.045) and to poor prognosis in cells with positive Ki67 status (p = 0.013). A high intensity of nuclear H3K4me3 staining was found to be correlated with a lower 10-year-survival (p = 0.026) and with lower breast cancer-specific survival (p = 0.004). High percentage score (> 190) of H3K9ac expression was correlated to worse breast cancer-specific survival (p = 0.005). Shorter progression-free survival was found in patients with nuclear (p = 0.013) and cytoplasmic H3K4me3expression (p = 0.024) and H3K9ac expression (p = 0.023). CONCLUSION: This analysis provides new evidence of histone modifications in breast cancer. High H3K4me3 and H3K9ac expression was correlated with survival rates. Further investigation of histone modifications in breast cancer could lead to a more profound understanding of the molecular mechanisms of cancer development and could result in new therapeutic strategies. Springer Berlin Heidelberg 2020-05-28 2020 /pmc/articles/PMC7324433/ /pubmed/32468423 http://dx.doi.org/10.1007/s00432-020-03265-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article – Cancer Research
Berger, Luisa
Kolben, Thomas
Meister, Sarah
Kolben, Theresa M.
Schmoeckel, Elisa
Mayr, Doris
Mahner, Sven
Jeschke, Udo
Ditsch, Nina
Beyer, Susanne
Expression of H3K4me3 and H3K9ac in breast cancer
title Expression of H3K4me3 and H3K9ac in breast cancer
title_full Expression of H3K4me3 and H3K9ac in breast cancer
title_fullStr Expression of H3K4me3 and H3K9ac in breast cancer
title_full_unstemmed Expression of H3K4me3 and H3K9ac in breast cancer
title_short Expression of H3K4me3 and H3K9ac in breast cancer
title_sort expression of h3k4me3 and h3k9ac in breast cancer
topic Original Article – Cancer Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324433/
https://www.ncbi.nlm.nih.gov/pubmed/32468423
http://dx.doi.org/10.1007/s00432-020-03265-z
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