Cargando…

Contractility of Induced Pluripotent Stem Cell-Cardiomyocytes With an MYH6 Head Domain Variant Associated With Hypoplastic Left Heart Syndrome

Hypoplastic left heart syndrome (HLHS) is a clinically and anatomically severe form of congenital heart disease; however, its etiology remains largely unknown. We previously demonstrated that genetic variants in the MYH6 gene are significantly associated with HLHS. Additionally, induced pluripotent...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Min-Su, Fleres, Brandon, Lovett, Jerrell, Anfinson, Melissa, Samudrala, Sai Suma K., Kelly, Lauren J., Teigen, Laura E., Cavanaugh, Matthew, Marquez, Maribel, Geurts, Aron M., Lough, John W., Mitchell, Michael E., Fitts, Robert H., Tomita-Mitchell, Aoy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324479/ https://www.ncbi.nlm.nih.gov/pubmed/32656206 http://dx.doi.org/10.3389/fcell.2020.00440

Ejemplares similares

Significance of α-Myosin Heavy Chain (MYH6) Variants in Hypoplastic Left Heart Syndrome and Related Cardiovascular Diseases
por: Anfinson, Melissa, et al.
Publicado: (2022)

77085 Impact of MYH6 Variants on Development and Clinical Course of Hypoplastic Left Heart Syndrome
por: Anfinson, Melissa, et al.
Publicado: (2021)

Impact of MYH6 variants in hypoplastic left heart syndrome
por: Tomita-Mitchell, Aoy, et al.
Publicado: (2016)

371 Decreased Contraction Rate, Altered Calcium Transients, and Increased Proliferation seen in Patient-specific iPSC-CMs Modeling Ebsteins Anomaly and Left Ventricular Noncompaction
por: Samudrala, Sai Suma, et al.
Publicado: (2022)

Data on the effects of ECM rigidity on actomyosin contractility and invadopodia activity in individual versus pairs of head and neck squamous cell carcinoma cells
por: Jerrell, Rachel, et al.
Publicado: (2021)

A Systematic Review of Ebstein’s Anomaly with Left Ventricular Noncompaction
por: Thareja, Suma K., et al.
Publicado: (2022)

Cardiomyocyte apoptosis contributes to contractile dysfunction in stem cell model of MYH7 E848G hypertrophic cardiomyopathy
por: Loiben, Alexander M., et al.
Publicado: (2023)

Cardiomyocyte Apoptosis Is Associated with Contractile Dysfunction in Stem Cell Model of MYH7 E848G Hypertrophic Cardiomyopathy
por: Loiben, Alexander M., et al.
Publicado: (2023)

MYH10 activation rescues contractile defects in arrhythmogenic cardiomyopathy (ACM)
por: García-Quintáns, Nieves, et al.
Publicado: (2023)

Prenatal diagnosis of recurrent hypoplastic left heart syndrome associated with MYH6 variants: a case report
por: Najib, B., et al.
Publicado: (2023)

Myocardial contractile response to dobutamine in hypoplastic left heart syndrome post-Fontan
por: Wong, James, et al.
Publicado: (2014)

GSEPD: a Bioconductor package for RNA-seq gene set enrichment and projection display
por: Stamm, Karl, et al.
Publicado: (2019)

Fractalkine Depresses Cardiomyocyte Contractility
por: Taube, David, et al.
Publicado: (2013)

Activin-A and Bmp4 Levels Modulate Cell Type Specification during CHIR-Induced Cardiomyogenesis
por: Kim, Min-Su, et al.
Publicado: (2015)

The altered mechanical phenotype of fetal fibroblasts hinders myofibroblast differentiation
por: Jerrell, Rachel J., et al.
Publicado: (2018)

The ROCK isoforms differentially regulate the morphological characteristics of carcinoma cells
por: Jerrell, Rachel J., et al.
Publicado: (2017)

Correction: Fractalkine Depresses Cardiomyocyte Contractility
por: Taube, David, et al.
Publicado: (2013)

An Myh11 single lysine deletion causes aortic dissection by reducing aortic structural integrity and contractility
por: Negishi, Keita, et al.
Publicado: (2022)

Approaches to High-Throughput Analysis of Cardiomyocyte Contractility
por: Wright, Peter T., et al.
Publicado: (2020)

Extracellular Matrix in Regulation of Contractile System in Cardiomyocytes
por: Bildyug, Natalya
Publicado: (2019)

Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity
por: Birker, Katja, et al.
Publicado: (2023)

Data on the mechanobiological differences in the transcriptomes of human fetal and adult dermal fibroblasts in response to extracellular matrix rigidity
por: Leih, Mitchell J., et al.
Publicado: (2019)

Vinculin anchors contractile actin to the cardiomyocyte adherens junction
por: Merkel, Chelsea D., et al.
Publicado: (2019)

Myofibre Hyper-Contractility in Horses Expressing the Myosin Heavy Chain Myopathy Mutation, MYH1(E321G)
por: Ochala, Julien, et al.
Publicado: (2021)

Single‐Cell Transcriptomics of Engineered Cardiac Tissues From Patient‐Specific Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Abnormal Developmental Trajectory and Intrinsic Contractile Defects in Hypoplastic Right Heart Syndrome
por: Lam, Yin‐Yu, et al.
Publicado: (2020)

Novel KLHL26 variant associated with a familial case of Ebstein’s anomaly and left ventricular noncompaction
por: Samudrala, Sai Suma K., et al.
Publicado: (2020)

Burst-Like Transcription of Mutant and Wildtype MYH7-Alleles as Possible Origin of Cell-to-Cell Contractile Imbalance in Hypertrophic Cardiomyopathy
por: Montag, Judith, et al.
Publicado: (2018)

Use of Metformin in Pulmonary Vein Stenosis after TAPVR Repair
por: Kirkpatrick, Edward C., et al.
Publicado: (2020)

MYH9 nephropathy
por: Oh, Taehoon, et al.
Publicado: (2015)

Cholesterol Depletion Alters Cardiomyocyte Subcellular Signaling and Increases Contractility
por: Haque, Mohammed Z., et al.
Publicado: (2016)

Cholesterol depletion impairs contractile machinery in neonatal rat cardiomyocytes
por: Hissa, Barbara, et al.
Publicado: (2017)

Optical-flow based non-invasive analysis of cardiomyocyte contractility
por: Czirok, Andras, et al.
Publicado: (2017)

Hypochlorite-Modified LDL Induces Arrhythmia and Contractile Dysfunction in Cardiomyocytes
por: Koyani, Chintan N., et al.
Publicado: (2021)

Defective Cardiomyocyte Maturation in the Congenitally Hypoplastic Right Ventricle: A Wrong Molecular Trajectory Leading to Heart Failure?
por: Madeddu, Paolo
Publicado: (2020)

Nonmuscle myosin 2 proteins encoded by Myh9, Myh10, and Myh14 are uniquely distributed in the tubular segments of murine kidney
por: Otterpohl, Karla L., et al.
Publicado: (2017)

Myh6-driven Cre recombinase activates the DNA damage response and the cell cycle in the myocardium in the absence of loxP sites
por: Wang, Xinrui, et al.
Publicado: (2020)

Fluorescent hiPSC-derived MYH6-mScarlet cardiomyocytes for real-time tracking, imaging, and cardiotoxicity assays
por: Maria Cherian, Reeja, et al.
Publicado: (2022)

Complexities of genetic diagnosis illustrated by an atypical case of congenital hypoplastic anemia
por: Claassen, David, et al.
Publicado: (2018)

Fibrinogen decreases cardiomyocyte contractility through an ICAM-1-dependent mechanism
por: Boyd, John H, et al.
Publicado: (2008)

Recent Insights in the Paracrine Modulation of Cardiomyocyte Contractility by Cardiac Endothelial Cells
por: Noireaud, Jacques, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_qcev3qi2quqkka2s59ha4l961b