Peptidylarginine Deiminase 4 Promotes the Renal Infiltration of Neutrophils and Exacerbates the TLR7 Agonist-Induced Lupus Mice

Peptidylarginine deiminase 4 (PAD4), encoded by PADI4, plays critical roles in the immune system; however, its contribution to the pathogenesis of lupus nephritis remains controversial. The pathological roles of PAD4 were investigated in lupus model mice. An imiquimod (IMQ)-induced lupus model was a...

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Detalles Bibliográficos
Autores principales: Hanata, Norio, Shoda, Hirofumi, Hatano, Hiroaki, Nagafuchi, Yasuo, Komai, Toshihiko, Okamura, Tomohisa, Suzuki, Akari, Gunarta, I Ketut, Yoshioka, Katsuji, Yamamoto, Kazuhiko, Fujio, Keishi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324481/
https://www.ncbi.nlm.nih.gov/pubmed/32655553
http://dx.doi.org/10.3389/fimmu.2020.01095

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