O-GlcNAcase contributes to cognitive function in Drosophila

O-GlcNAcylation is an abundant post-translational modification in neurons. In mice, an increase in O-GlcNAcylation leads to defects in hippocampal synaptic plasticity and learning. O-GlcNAcylation is established by two opposing enzymes: O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). To investigat...

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Detalles Bibliográficos
Autores principales: Muha, Villo, Fenckova, Michaela, Ferenbach, Andrew T., Catinozzi, Marica, Eidhof, Ilse, Storkebaum, Erik, Schenck, Annette, van Aalten, Daan M. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Glycobiology and Extracellular Matrices
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324509/
https://www.ncbi.nlm.nih.gov/pubmed/32094227
http://dx.doi.org/10.1074/jbc.RA119.010312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324509/
https://www.ncbi.nlm.nih.gov/pubmed/32094227
http://dx.doi.org/10.1074/jbc.RA119.010312

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