Cargando…

O-GlcNAcase contributes to cognitive function in Drosophila

O-GlcNAcylation is an abundant post-translational modification in neurons. In mice, an increase in O-GlcNAcylation leads to defects in hippocampal synaptic plasticity and learning. O-GlcNAcylation is established by two opposing enzymes: O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). To investigat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Muha, Villo, Fenckova, Michaela, Ferenbach, Andrew T., Catinozzi, Marica, Eidhof, Ilse, Storkebaum, Erik, Schenck, Annette, van Aalten, Daan M. F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Glycobiology and Extracellular Matrices
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324509/ https://www.ncbi.nlm.nih.gov/pubmed/32094227 http://dx.doi.org/10.1074/jbc.RA119.010312

Ejemplares similares

Effects of hypo-O-GlcNAcylation on Drosophila development
por: Mariappa, Daniel, et al.
Publicado: (2018)

The Early Metazoan Trichoplax adhaerens Possesses a Functional O-GlcNAc System
por: Selvan, Nithya, et al.
Publicado: (2015)

Intellectual disability-associated disruption of O-GlcNAc cycling impairs habituation learning in Drosophila
por: Fenckova, Michaela, et al.
Publicado: (2022)

A Structural and Biochemical Model of Processive Chitin Synthesis
por: Dorfmueller, Helge C., et al.
Publicado: (2014)

The conserved threonine-rich region of the HCF-1(PRO) repeat activates promiscuous OGT:UDP-GlcNAc glycosylation and proteolysis activities
por: Kapuria, Vaibhav, et al.
Publicado: (2018)

Loss of O-GlcNAcase catalytic activity leads to defects in mouse embryogenesis
por: Muha, Villő, et al.
Publicado: (2021)

Binding of N-Acetylglucosamine (GlcNAc) β1–6-branched Oligosaccharide Acceptors to β4-Galactosyltransferase I Reveals a New Ligand Binding Mode
por: Ramakrishnan, Boopathy, et al.
Publicado: (2012)

Synergy of Peptide and Sugar in O-GlcNAcase Substrate Recognition
por: Schimpl, Marianne, et al.
Publicado: (2012)

O-GlcNAcase: Promiscuous Hexosaminidase or Key Regulator of O-GlcNAc Signaling?
por: Alonso, Jana, et al.
Publicado: (2014)

A Mucin-type O-Glycosyltransferase Modulates Cell Adhesion during Drosophila Development
por: Zhang, Liping, et al.
Publicado: (2008)

Screening-based discovery of drug-like O-GlcNAcase inhibitor scaffolds
por: Dorfmueller, Helge C., et al.
Publicado: (2010)

Structure of a bacterial putative acetyltransferase defines the fold of the human O-GlcNAcase C-terminal domain
por: Rao, Francesco V., et al.
Publicado: (2013)

GlcNAcstatins are nanomolar inhibitors of human O-GlcNAcase inducing cellular hyper-O-GlcNAcylation
por: Dorfmueller, Helge C., et al.
Publicado: (2009)

CLEC9A Is a Novel Activation C-type Lectin-like Receptor Expressed on BDCA3(+) Dendritic Cells and a Subset of Monocytes
por: Huysamen, Cristal, et al.
Publicado: (2008)

The Synthesis of UDP-N-acetylglucosamine Is Essential for Bloodstream Form Trypanosoma brucei in Vitro and in Vivo and UDP-N-acetylglucosamine Starvation Reveals a Hierarchy in Parasite Protein Glycosylation
por: Stokes, Matthew J., et al.
Publicado: (2008)

TSG-6 Regulates Bone Remodeling through Inhibition of Osteoblastogenesis and Osteoclast Activation
por: Mahoney, David J., et al.
Publicado: (2008)

Identification of Neutrophil Granule Glycoproteins as Lewis(x)-containing Ligands Cleared by the Scavenger Receptor C-type Lectin
por: Graham, Sarah A., et al.
Publicado: (2011)

Peracetylated 4-Fluoro-glucosamine Reduces the Content and Repertoire of N- and O-Glycans without Direct Incorporation
por: Barthel, Steven R., et al.
Publicado: (2011)

Early Murine T-lymphocyte Activation Is Accompanied by a Switch from N-Glycolyl- to N-Acetyl-neuraminic Acid and Generation of Ligands for Siglec-E
por: Redelinghuys, Pierre, et al.
Publicado: (2011)

Lectin Domains of Polypeptide GalNAc Transferases Exhibit Glycopeptide Binding Specificity
por: Pedersen, Johannes W., et al.
Publicado: (2011)

Post-assembly Modification of Bordetella bronchiseptica O Polysaccharide by a Novel Periplasmic Enzyme Encoded by wbmE
por: King, Jerry D., et al.
Publicado: (2009)

Interleukin-6 Released from Fibroblasts Is Essential for Up-regulation of Matrix Metalloproteinase-1 Expression by U937 Macrophages in Coculture: CROSS-TALKING BETWEEN FIBROBLASTS AND U937 MACROPHAGES EXPOSED TO HIGH GLUCOSE
por: Sundararaj, Kamala P., et al.
Publicado: (2009)

Loss of α-Dystroglycan Laminin Binding in Epithelium-derived Cancers Is Caused by Silencing of LARGE
por: de Bernabé, Daniel Beltrán-Valero, et al.
Publicado: (2009)

A Human Embryonic Kidney 293T Cell Line Mutated at the Golgi α-Mannosidase II Locus
por: Crispin, Max, et al.
Publicado: (2009)

Rapid Purification and High Sensitivity Analysis of Heparan Sulfate from Cells and Tissues: TOWARD GLYCOMICS PROFILING
por: Guimond, Scott E., et al.
Publicado: (2009)

Trimeric Structure of Langerin
por: Feinberg, Hadar, et al.
Publicado: (2010)

Heparan Sulfate Chain Valency Controls Syndecan-4 Function in Cell Adhesion
por: Gopal, Sandeep, et al.
Publicado: (2010)

α2,6-Sialic Acid on Platelet Endothelial Cell Adhesion Molecule (PECAM) Regulates Its Homophilic Interactions and Downstream Antiapoptotic Signaling
por: Kitazume, Shinobu, et al.
Publicado: (2010)

Glycomics Profiling of Chinese Hamster Ovary Cell Glycosylation Mutants Reveals N-Glycans of a Novel Size and Complexity
por: North, Simon J., et al.
Publicado: (2010)

Revised Role of Glycosaminoglycans in TAT Protein Transduction Domain-mediated Cellular Transduction
por: Gump, Jacob M., et al.
Publicado: (2010)

Prolectin, a Glycan-binding Receptor on Dividing B Cells in Germinal Centers
por: Graham, Sarah A., et al.
Publicado: (2009)

In Planta Protein Sialylation through Overexpression of the Respective Mammalian Pathway
por: Castilho, Alexandra, et al.
Publicado: (2010)

Role of the Netrin-like Domain of Procollagen C-Proteinase Enhancer-1 in the Control of Metalloproteinase Activity
por: Bekhouche, Mourad, et al.
Publicado: (2010)

Identification of Mono- and Disulfated N-Acetyl-lactosaminyl Oligosaccharide Structures as Epitopes Specifically Recognized by Humanized Monoclonal Antibody HMOCC-1 Raised against Ovarian Cancer
por: Shibata, Toshiaki K., et al.
Publicado: (2012)

Constitutive Expression of Inter-α-inhibitor (IαI) Family Proteins and Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) by Human Amniotic Membrane Epithelial and Stromal Cells Supporting Formation of the Heavy Chain-Hyaluronan (HC-HA) Complex
por: Zhang, Suzhen, et al.
Publicado: (2012)

Monocyte-to-Macrophage Differentiation: SYNTHESIS AND SECRETION OF A COMPLEX EXTRACELLULAR MATRIX
por: Chang, Mary Y., et al.
Publicado: (2012)

Transglutaminase-2 Interaction with Heparin: IDENTIFICATION OF A HEPARIN BINDING SITE THAT REGULATES CELL ADHESION TO FIBRONECTIN-TRANSGLUTAMINASE-2 MATRIX
por: Lortat-Jacob, Hugues, et al.
Publicado: (2012)

Chemical Structure of Trichomonas vaginalis Surface Lipoglycan: A ROLE FOR SHORT GALACTOSE (β1–4/3) N-ACETYLGLUCOSAMINE REPEATS IN HOST CELL INTERACTION
por: Ryan, Christopher M., et al.
Publicado: (2011)

Collagen VI, Conformation of A-domain Arrays and Microfibril Architecture
por: Beecher, Nicola, et al.
Publicado: (2011)

The Streptococcal Binding Site in the Gelatin-binding Domain of Fibronectin Is Consistent with a Non-linear Arrangement of Modules
por: Atkin, Kate E., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_q04aneem6v9tutune42048vs1f