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KCNQs: Ligand- and Voltage-Gated Potassium Channels

Voltage-gated potassium (Kv) channels in the KCNQ (Kv7) family are essential features of a broad range of excitable and non-excitable cell types and are found in organisms ranging from Hydra vulgaris to Homo sapiens. Although they are firmly in the superfamily of S4 domain-bearing voltage-sensing io...

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Autor principal: Abbott, Geoffrey W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324551/
https://www.ncbi.nlm.nih.gov/pubmed/32655402
http://dx.doi.org/10.3389/fphys.2020.00583
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author Abbott, Geoffrey W.
author_facet Abbott, Geoffrey W.
author_sort Abbott, Geoffrey W.
collection PubMed
description Voltage-gated potassium (Kv) channels in the KCNQ (Kv7) family are essential features of a broad range of excitable and non-excitable cell types and are found in organisms ranging from Hydra vulgaris to Homo sapiens. Although they are firmly in the superfamily of S4 domain-bearing voltage-sensing ion channels, KCNQ channels are highly sensitive to a range of endogenous and exogenous small molecules that act directly on the pore, the voltage-sensing domain, or the interface between the two. The focus of this review is regulation of KCNQs by direct binding of neurotransmitters and metabolites from both animals and plants and the role of the latter in the effects of plants consumed for food and as traditional folk medicines. The conceptual question arises: Are KCNQs voltage-gated channels that are also sensitive to ligands or ligand-gated channels that are also sensitive to voltage?
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spelling pubmed-73245512020-07-10 KCNQs: Ligand- and Voltage-Gated Potassium Channels Abbott, Geoffrey W. Front Physiol Physiology Voltage-gated potassium (Kv) channels in the KCNQ (Kv7) family are essential features of a broad range of excitable and non-excitable cell types and are found in organisms ranging from Hydra vulgaris to Homo sapiens. Although they are firmly in the superfamily of S4 domain-bearing voltage-sensing ion channels, KCNQ channels are highly sensitive to a range of endogenous and exogenous small molecules that act directly on the pore, the voltage-sensing domain, or the interface between the two. The focus of this review is regulation of KCNQs by direct binding of neurotransmitters and metabolites from both animals and plants and the role of the latter in the effects of plants consumed for food and as traditional folk medicines. The conceptual question arises: Are KCNQs voltage-gated channels that are also sensitive to ligands or ligand-gated channels that are also sensitive to voltage? Frontiers Media S.A. 2020-06-23 /pmc/articles/PMC7324551/ /pubmed/32655402 http://dx.doi.org/10.3389/fphys.2020.00583 Text en Copyright © 2020 Abbott. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Abbott, Geoffrey W.
KCNQs: Ligand- and Voltage-Gated Potassium Channels
title KCNQs: Ligand- and Voltage-Gated Potassium Channels
title_full KCNQs: Ligand- and Voltage-Gated Potassium Channels
title_fullStr KCNQs: Ligand- and Voltage-Gated Potassium Channels
title_full_unstemmed KCNQs: Ligand- and Voltage-Gated Potassium Channels
title_short KCNQs: Ligand- and Voltage-Gated Potassium Channels
title_sort kcnqs: ligand- and voltage-gated potassium channels
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324551/
https://www.ncbi.nlm.nih.gov/pubmed/32655402
http://dx.doi.org/10.3389/fphys.2020.00583
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