Activity-Based Protein Profiling Reveals That Cephalosporins Selectively Active on Non-replicating Mycobacterium tuberculosis Bind Multiple Protein Families and Spare Peptidoglycan Transpeptidases

As β-lactams are reconsidered for the treatment of tuberculosis (TB), their targets are assumed to be peptidoglycan transpeptidases, as verified by adduct formation and kinetic inhibition of Mycobacterium tuberculosis (Mtb) transpeptidases by carbapenems active against replicating Mtb. Here, we inve...

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Detalles Bibliográficos
Autores principales: Lopez Quezada, Landys, Smith, Robert, Lupoli, Tania J., Edoo, Zainab, Li, Xiaojun, Gold, Ben, Roberts, Julia, Ling, Yan, Park, Sae Woong, Nguyen, Quyen, Schoenen, Frank J., Li, Kelin, Hugonnet, Jean-Emmanuel, Arthur, Michel, Sacchettini, James C., Nathan, Carl, Aubé, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324553/
https://www.ncbi.nlm.nih.gov/pubmed/32655524
http://dx.doi.org/10.3389/fmicb.2020.01248

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