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AAV8 Ins1-Cre can produce efficient β-cell recombination but requires consideration of off-target effects

In vivo genetic manipulation is used to study the impact of gene deletion or re-expression on β-cell function and organism physiology. Cre-LoxP is a system wherein LoxP sites flanking a gene are recognized by Cre recombinase. Cre transgenic mice are the most prevalent technology used to deliver Cre...

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Detalles Bibliográficos
Autores principales:	Ramzy, Adam, Tudurí, Eva, Glavas, Maria M., Baker, Robert K., Mojibian, Majid, Fox, Jessica K., O’Dwyer, Shannon M., Dai, Derek, Hu, Xiaoke, Denroche, Heather C., Edeer, Nazde, Gray, Sarah L., Verchere, Cameron B., Johnson, James D., Kieffer, Timothy J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324556/ https://www.ncbi.nlm.nih.gov/pubmed/32601405 http://dx.doi.org/10.1038/s41598-020-67136-w

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