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Iron imaging in myocardial infarction reperfusion injury
Restoration of coronary blood flow after a heart attack can cause reperfusion injury potentially leading to impaired cardiac function, adverse tissue remodeling and heart failure. Iron is an essential biometal that may have a pathologic role in this process. There is a clinical need for a precise no...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324567/ https://www.ncbi.nlm.nih.gov/pubmed/32601301 http://dx.doi.org/10.1038/s41467-020-16923-0 |
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author | Moon, Brianna F. Iyer, Srikant Kamesh Hwuang, Eileen Solomon, Michael P. Hall, Anya T. Kumar, Rishabh Josselyn, Nicholas J. Higbee-Dempsey, Elizabeth M. Tsourkas, Andrew Imai, Akito Okamoto, Keitaro Saito, Yoshiaki Pilla, James J. Gorman, Joseph H. Gorman, Robert C. Tschabrunn, Cory Keeney, Samuel J. Castillero, Estibaliz Ferrari, Giovanni Jockusch, Steffen Wehrli, Felix W. Shou, Haochang Ferrari, Victor A. Han, Yuchi Gulhane, Avanti Litt, Harold Matthai, William Witschey, Walter R. |
author_facet | Moon, Brianna F. Iyer, Srikant Kamesh Hwuang, Eileen Solomon, Michael P. Hall, Anya T. Kumar, Rishabh Josselyn, Nicholas J. Higbee-Dempsey, Elizabeth M. Tsourkas, Andrew Imai, Akito Okamoto, Keitaro Saito, Yoshiaki Pilla, James J. Gorman, Joseph H. Gorman, Robert C. Tschabrunn, Cory Keeney, Samuel J. Castillero, Estibaliz Ferrari, Giovanni Jockusch, Steffen Wehrli, Felix W. Shou, Haochang Ferrari, Victor A. Han, Yuchi Gulhane, Avanti Litt, Harold Matthai, William Witschey, Walter R. |
author_sort | Moon, Brianna F. |
collection | PubMed |
description | Restoration of coronary blood flow after a heart attack can cause reperfusion injury potentially leading to impaired cardiac function, adverse tissue remodeling and heart failure. Iron is an essential biometal that may have a pathologic role in this process. There is a clinical need for a precise noninvasive method to detect iron for risk stratification of patients and therapy evaluation. Here, we report that magnetic susceptibility imaging in a large animal model shows an infarct paramagnetic shift associated with duration of coronary artery occlusion and the presence of iron. Iron validation techniques used include histology, immunohistochemistry, spectrometry and spectroscopy. Further mRNA analysis shows upregulation of ferritin and heme oxygenase. While conventional imaging corroborates the findings of iron deposition, magnetic susceptibility imaging has improved sensitivity to iron and mitigates confounding factors such as edema and fibrosis. Myocardial infarction patients receiving reperfusion therapy show magnetic susceptibility changes associated with hypokinetic myocardial wall motion and microvascular obstruction, demonstrating potential for clinical translation. |
format | Online Article Text |
id | pubmed-7324567 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-73245672020-07-06 Iron imaging in myocardial infarction reperfusion injury Moon, Brianna F. Iyer, Srikant Kamesh Hwuang, Eileen Solomon, Michael P. Hall, Anya T. Kumar, Rishabh Josselyn, Nicholas J. Higbee-Dempsey, Elizabeth M. Tsourkas, Andrew Imai, Akito Okamoto, Keitaro Saito, Yoshiaki Pilla, James J. Gorman, Joseph H. Gorman, Robert C. Tschabrunn, Cory Keeney, Samuel J. Castillero, Estibaliz Ferrari, Giovanni Jockusch, Steffen Wehrli, Felix W. Shou, Haochang Ferrari, Victor A. Han, Yuchi Gulhane, Avanti Litt, Harold Matthai, William Witschey, Walter R. Nat Commun Article Restoration of coronary blood flow after a heart attack can cause reperfusion injury potentially leading to impaired cardiac function, adverse tissue remodeling and heart failure. Iron is an essential biometal that may have a pathologic role in this process. There is a clinical need for a precise noninvasive method to detect iron for risk stratification of patients and therapy evaluation. Here, we report that magnetic susceptibility imaging in a large animal model shows an infarct paramagnetic shift associated with duration of coronary artery occlusion and the presence of iron. Iron validation techniques used include histology, immunohistochemistry, spectrometry and spectroscopy. Further mRNA analysis shows upregulation of ferritin and heme oxygenase. While conventional imaging corroborates the findings of iron deposition, magnetic susceptibility imaging has improved sensitivity to iron and mitigates confounding factors such as edema and fibrosis. Myocardial infarction patients receiving reperfusion therapy show magnetic susceptibility changes associated with hypokinetic myocardial wall motion and microvascular obstruction, demonstrating potential for clinical translation. Nature Publishing Group UK 2020-06-29 /pmc/articles/PMC7324567/ /pubmed/32601301 http://dx.doi.org/10.1038/s41467-020-16923-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Moon, Brianna F. Iyer, Srikant Kamesh Hwuang, Eileen Solomon, Michael P. Hall, Anya T. Kumar, Rishabh Josselyn, Nicholas J. Higbee-Dempsey, Elizabeth M. Tsourkas, Andrew Imai, Akito Okamoto, Keitaro Saito, Yoshiaki Pilla, James J. Gorman, Joseph H. Gorman, Robert C. Tschabrunn, Cory Keeney, Samuel J. Castillero, Estibaliz Ferrari, Giovanni Jockusch, Steffen Wehrli, Felix W. Shou, Haochang Ferrari, Victor A. Han, Yuchi Gulhane, Avanti Litt, Harold Matthai, William Witschey, Walter R. Iron imaging in myocardial infarction reperfusion injury |
title | Iron imaging in myocardial infarction reperfusion injury |
title_full | Iron imaging in myocardial infarction reperfusion injury |
title_fullStr | Iron imaging in myocardial infarction reperfusion injury |
title_full_unstemmed | Iron imaging in myocardial infarction reperfusion injury |
title_short | Iron imaging in myocardial infarction reperfusion injury |
title_sort | iron imaging in myocardial infarction reperfusion injury |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324567/ https://www.ncbi.nlm.nih.gov/pubmed/32601301 http://dx.doi.org/10.1038/s41467-020-16923-0 |
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