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Iron imaging in myocardial infarction reperfusion injury

Restoration of coronary blood flow after a heart attack can cause reperfusion injury potentially leading to impaired cardiac function, adverse tissue remodeling and heart failure. Iron is an essential biometal that may have a pathologic role in this process. There is a clinical need for a precise no...

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Autores principales: Moon, Brianna F., Iyer, Srikant Kamesh, Hwuang, Eileen, Solomon, Michael P., Hall, Anya T., Kumar, Rishabh, Josselyn, Nicholas J., Higbee-Dempsey, Elizabeth M., Tsourkas, Andrew, Imai, Akito, Okamoto, Keitaro, Saito, Yoshiaki, Pilla, James J., Gorman, Joseph H., Gorman, Robert C., Tschabrunn, Cory, Keeney, Samuel J., Castillero, Estibaliz, Ferrari, Giovanni, Jockusch, Steffen, Wehrli, Felix W., Shou, Haochang, Ferrari, Victor A., Han, Yuchi, Gulhane, Avanti, Litt, Harold, Matthai, William, Witschey, Walter R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324567/
https://www.ncbi.nlm.nih.gov/pubmed/32601301
http://dx.doi.org/10.1038/s41467-020-16923-0
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author Moon, Brianna F.
Iyer, Srikant Kamesh
Hwuang, Eileen
Solomon, Michael P.
Hall, Anya T.
Kumar, Rishabh
Josselyn, Nicholas J.
Higbee-Dempsey, Elizabeth M.
Tsourkas, Andrew
Imai, Akito
Okamoto, Keitaro
Saito, Yoshiaki
Pilla, James J.
Gorman, Joseph H.
Gorman, Robert C.
Tschabrunn, Cory
Keeney, Samuel J.
Castillero, Estibaliz
Ferrari, Giovanni
Jockusch, Steffen
Wehrli, Felix W.
Shou, Haochang
Ferrari, Victor A.
Han, Yuchi
Gulhane, Avanti
Litt, Harold
Matthai, William
Witschey, Walter R.
author_facet Moon, Brianna F.
Iyer, Srikant Kamesh
Hwuang, Eileen
Solomon, Michael P.
Hall, Anya T.
Kumar, Rishabh
Josselyn, Nicholas J.
Higbee-Dempsey, Elizabeth M.
Tsourkas, Andrew
Imai, Akito
Okamoto, Keitaro
Saito, Yoshiaki
Pilla, James J.
Gorman, Joseph H.
Gorman, Robert C.
Tschabrunn, Cory
Keeney, Samuel J.
Castillero, Estibaliz
Ferrari, Giovanni
Jockusch, Steffen
Wehrli, Felix W.
Shou, Haochang
Ferrari, Victor A.
Han, Yuchi
Gulhane, Avanti
Litt, Harold
Matthai, William
Witschey, Walter R.
author_sort Moon, Brianna F.
collection PubMed
description Restoration of coronary blood flow after a heart attack can cause reperfusion injury potentially leading to impaired cardiac function, adverse tissue remodeling and heart failure. Iron is an essential biometal that may have a pathologic role in this process. There is a clinical need for a precise noninvasive method to detect iron for risk stratification of patients and therapy evaluation. Here, we report that magnetic susceptibility imaging in a large animal model shows an infarct paramagnetic shift associated with duration of coronary artery occlusion and the presence of iron. Iron validation techniques used include histology, immunohistochemistry, spectrometry and spectroscopy. Further mRNA analysis shows upregulation of ferritin and heme oxygenase. While conventional imaging corroborates the findings of iron deposition, magnetic susceptibility imaging has improved sensitivity to iron and mitigates confounding factors such as edema and fibrosis. Myocardial infarction patients receiving reperfusion therapy show magnetic susceptibility changes associated with hypokinetic myocardial wall motion and microvascular obstruction, demonstrating potential for clinical translation.
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spelling pubmed-73245672020-07-06 Iron imaging in myocardial infarction reperfusion injury Moon, Brianna F. Iyer, Srikant Kamesh Hwuang, Eileen Solomon, Michael P. Hall, Anya T. Kumar, Rishabh Josselyn, Nicholas J. Higbee-Dempsey, Elizabeth M. Tsourkas, Andrew Imai, Akito Okamoto, Keitaro Saito, Yoshiaki Pilla, James J. Gorman, Joseph H. Gorman, Robert C. Tschabrunn, Cory Keeney, Samuel J. Castillero, Estibaliz Ferrari, Giovanni Jockusch, Steffen Wehrli, Felix W. Shou, Haochang Ferrari, Victor A. Han, Yuchi Gulhane, Avanti Litt, Harold Matthai, William Witschey, Walter R. Nat Commun Article Restoration of coronary blood flow after a heart attack can cause reperfusion injury potentially leading to impaired cardiac function, adverse tissue remodeling and heart failure. Iron is an essential biometal that may have a pathologic role in this process. There is a clinical need for a precise noninvasive method to detect iron for risk stratification of patients and therapy evaluation. Here, we report that magnetic susceptibility imaging in a large animal model shows an infarct paramagnetic shift associated with duration of coronary artery occlusion and the presence of iron. Iron validation techniques used include histology, immunohistochemistry, spectrometry and spectroscopy. Further mRNA analysis shows upregulation of ferritin and heme oxygenase. While conventional imaging corroborates the findings of iron deposition, magnetic susceptibility imaging has improved sensitivity to iron and mitigates confounding factors such as edema and fibrosis. Myocardial infarction patients receiving reperfusion therapy show magnetic susceptibility changes associated with hypokinetic myocardial wall motion and microvascular obstruction, demonstrating potential for clinical translation. Nature Publishing Group UK 2020-06-29 /pmc/articles/PMC7324567/ /pubmed/32601301 http://dx.doi.org/10.1038/s41467-020-16923-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Moon, Brianna F.
Iyer, Srikant Kamesh
Hwuang, Eileen
Solomon, Michael P.
Hall, Anya T.
Kumar, Rishabh
Josselyn, Nicholas J.
Higbee-Dempsey, Elizabeth M.
Tsourkas, Andrew
Imai, Akito
Okamoto, Keitaro
Saito, Yoshiaki
Pilla, James J.
Gorman, Joseph H.
Gorman, Robert C.
Tschabrunn, Cory
Keeney, Samuel J.
Castillero, Estibaliz
Ferrari, Giovanni
Jockusch, Steffen
Wehrli, Felix W.
Shou, Haochang
Ferrari, Victor A.
Han, Yuchi
Gulhane, Avanti
Litt, Harold
Matthai, William
Witschey, Walter R.
Iron imaging in myocardial infarction reperfusion injury
title Iron imaging in myocardial infarction reperfusion injury
title_full Iron imaging in myocardial infarction reperfusion injury
title_fullStr Iron imaging in myocardial infarction reperfusion injury
title_full_unstemmed Iron imaging in myocardial infarction reperfusion injury
title_short Iron imaging in myocardial infarction reperfusion injury
title_sort iron imaging in myocardial infarction reperfusion injury
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324567/
https://www.ncbi.nlm.nih.gov/pubmed/32601301
http://dx.doi.org/10.1038/s41467-020-16923-0
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