Doublecortin-like kinase 1 promotes hepatocyte clonogenicity and oncogenic programming via non-canonical β-catenin-dependent mechanism

Chronic liver injury is a risk factor for cirrhosis and hepatocellular carcinoma (HCC). The molecular mechanisms that regulate the decision between normal injury repair and neoplastic initiation are unclear. Doublecortin-like kinase 1 (DCLK1), a tumor stem cell marker, is induced during cirrhosis an...

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Detalles Bibliográficos
Autores principales: Ali, Naushad, Nguyen, Charles B., Chandrakesan, Parthasarathy, Wolf, Roman F., Qu, Dongfeng, May, Randal, Goretsky, Tatiana, Fazili, Javid, Barrett, Terrence A., Li, Min, Huycke, Mark M., Bronze, Michael S., Houchen, Courtney W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324569/
https://www.ncbi.nlm.nih.gov/pubmed/32601309
http://dx.doi.org/10.1038/s41598-020-67401-y

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