A novel FRET peptide assay reveals efficient Helicobacter pylori HtrA inhibition through zinc and copper binding

Helicobacter pylori (H. pylori) secretes the chaperone and serine protease high temperature requirement A (HtrA) that cleaves gastric epithelial cell surface proteins to disrupt the epithelial integrity and barrier function. First inhibitory lead structures have demonstrated the essential role of Ht...

Descripción completa

Detalles Bibliográficos
Autores principales: Bernegger, Sabine, Brunner, Cyrill, Vizovišek, Matej, Fonovic, Marko, Cuciniello, Gaetano, Giordano, Flavia, Stanojlovic, Vesna, Jarzab, Miroslaw, Simister, Philip, Feller, Stephan M., Obermeyer, Gerhard, Posselt, Gernot, Turk, Boris, Cabrele, Chiara, Schneider, Gisbert, Wessler, Silja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324608/
https://www.ncbi.nlm.nih.gov/pubmed/32601479
http://dx.doi.org/10.1038/s41598-020-67578-2

Ejemplares similares

Ejemplares similares