Ultrasensitive amplicon barcoding for next-generation sequencing facilitating sequence error and amplification-bias correction

The ability to accurately characterize DNA variant proportions using PCR amplification is key to many genetic studies, including studying tumor heterogeneity, 16S microbiome, viral and immune receptor sequencing. We develop a novel generalizable ultrasensitive amplicon barcoding approach that signif...

Descripción completa

Detalles Bibliográficos
Autores principales: Ahmed, Ibrahim, Tucci, Felicia A., Aflalo, Aure, Smith, Kenneth G. C., Bashford-Rogers, Rachael J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324614/
https://www.ncbi.nlm.nih.gov/pubmed/32601361
http://dx.doi.org/10.1038/s41598-020-67290-1

Ejemplares similares

Ejemplares similares