A Potential Mechanism of Temozolomide Resistance in Glioma–Ferroptosis

Temozolomide (TMZ) is the first-line chemotherapy drug that has been used to treat glioma for over a decade, but the benefits are limited by half of the treated patients who acquired resistance. Studies have shown that glioma TMZ resistance is a complex process with multiple factors, which has not b...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Zhifang, Mi, Yajing, Qian, Huiming, Guo, Na, Yan, Aili, Zhang, Yuelin, Gao, Xingchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324762/
https://www.ncbi.nlm.nih.gov/pubmed/32656078
http://dx.doi.org/10.3389/fonc.2020.00897
_version_ 1783552011269046272
author Hu, Zhifang
Mi, Yajing
Qian, Huiming
Guo, Na
Yan, Aili
Zhang, Yuelin
Gao, Xingchun
author_facet Hu, Zhifang
Mi, Yajing
Qian, Huiming
Guo, Na
Yan, Aili
Zhang, Yuelin
Gao, Xingchun
author_sort Hu, Zhifang
collection PubMed
description Temozolomide (TMZ) is the first-line chemotherapy drug that has been used to treat glioma for over a decade, but the benefits are limited by half of the treated patients who acquired resistance. Studies have shown that glioma TMZ resistance is a complex process with multiple factors, which has not been fully elucidated. Ferroptosis, which is a new type of cell death discovered in recent years, has been reported to play an important role in tumor drug resistance. The present study reviews the relationship between ferroptosis and glioma TMZ resistance, and highlights the role of ferroptosis in glioma TMZ resistance. Finally, the investigators discussed the future orientation for ferroptosis in glioma TMZ resistance, in order to promote the clinical use of ferroptosis induction in glioma treatment.
format Online
Article
Text
id pubmed-7324762
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-73247622020-07-10 A Potential Mechanism of Temozolomide Resistance in Glioma–Ferroptosis Hu, Zhifang Mi, Yajing Qian, Huiming Guo, Na Yan, Aili Zhang, Yuelin Gao, Xingchun Front Oncol Oncology Temozolomide (TMZ) is the first-line chemotherapy drug that has been used to treat glioma for over a decade, but the benefits are limited by half of the treated patients who acquired resistance. Studies have shown that glioma TMZ resistance is a complex process with multiple factors, which has not been fully elucidated. Ferroptosis, which is a new type of cell death discovered in recent years, has been reported to play an important role in tumor drug resistance. The present study reviews the relationship between ferroptosis and glioma TMZ resistance, and highlights the role of ferroptosis in glioma TMZ resistance. Finally, the investigators discussed the future orientation for ferroptosis in glioma TMZ resistance, in order to promote the clinical use of ferroptosis induction in glioma treatment. Frontiers Media S.A. 2020-06-23 /pmc/articles/PMC7324762/ /pubmed/32656078 http://dx.doi.org/10.3389/fonc.2020.00897 Text en Copyright © 2020 Hu, Mi, Qian, Guo, Yan, Zhang and Gao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Hu, Zhifang
Mi, Yajing
Qian, Huiming
Guo, Na
Yan, Aili
Zhang, Yuelin
Gao, Xingchun
A Potential Mechanism of Temozolomide Resistance in Glioma–Ferroptosis
title A Potential Mechanism of Temozolomide Resistance in Glioma–Ferroptosis
title_full A Potential Mechanism of Temozolomide Resistance in Glioma–Ferroptosis
title_fullStr A Potential Mechanism of Temozolomide Resistance in Glioma–Ferroptosis
title_full_unstemmed A Potential Mechanism of Temozolomide Resistance in Glioma–Ferroptosis
title_short A Potential Mechanism of Temozolomide Resistance in Glioma–Ferroptosis
title_sort potential mechanism of temozolomide resistance in glioma–ferroptosis
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324762/
https://www.ncbi.nlm.nih.gov/pubmed/32656078
http://dx.doi.org/10.3389/fonc.2020.00897
work_keys_str_mv AT huzhifang apotentialmechanismoftemozolomideresistanceingliomaferroptosis
AT miyajing apotentialmechanismoftemozolomideresistanceingliomaferroptosis
AT qianhuiming apotentialmechanismoftemozolomideresistanceingliomaferroptosis
AT guona apotentialmechanismoftemozolomideresistanceingliomaferroptosis
AT yanaili apotentialmechanismoftemozolomideresistanceingliomaferroptosis
AT zhangyuelin apotentialmechanismoftemozolomideresistanceingliomaferroptosis
AT gaoxingchun apotentialmechanismoftemozolomideresistanceingliomaferroptosis
AT huzhifang potentialmechanismoftemozolomideresistanceingliomaferroptosis
AT miyajing potentialmechanismoftemozolomideresistanceingliomaferroptosis
AT qianhuiming potentialmechanismoftemozolomideresistanceingliomaferroptosis
AT guona potentialmechanismoftemozolomideresistanceingliomaferroptosis
AT yanaili potentialmechanismoftemozolomideresistanceingliomaferroptosis
AT zhangyuelin potentialmechanismoftemozolomideresistanceingliomaferroptosis
AT gaoxingchun potentialmechanismoftemozolomideresistanceingliomaferroptosis

Ejemplares similares