Neuregulin, an Effector on Mitochondria Metabolism That Preserves Insulin Sensitivity

Various external factors modulate the metabolic efficiency of mitochondria. This review focuses on the impact of the growth factor neuregulin and its ErbB receptors on mitochondria and their relationship with several physiopathological alterations. Neuregulin is involved in the differentiation of he...

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Autores principales: Gumà, Anna, Díaz-Sáez, Francisco, Camps, Marta, Zorzano, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324780/
https://www.ncbi.nlm.nih.gov/pubmed/32655416
http://dx.doi.org/10.3389/fphys.2020.00696
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author Gumà, Anna
Díaz-Sáez, Francisco
Camps, Marta
Zorzano, Antonio
author_facet Gumà, Anna
Díaz-Sáez, Francisco
Camps, Marta
Zorzano, Antonio
author_sort Gumà, Anna
collection PubMed
description Various external factors modulate the metabolic efficiency of mitochondria. This review focuses on the impact of the growth factor neuregulin and its ErbB receptors on mitochondria and their relationship with several physiopathological alterations. Neuregulin is involved in the differentiation of heart, skeletal muscle, and the neuronal system, among others; and its deficiency is deleterious for the health. Information gathered over the last two decades suggests that neuregulin plays a key role in regulating the mitochondrial oxidative machinery, which sustains cell survival and insulin sensitivity.
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spelling pubmed-73247802020-07-10 Neuregulin, an Effector on Mitochondria Metabolism That Preserves Insulin Sensitivity Gumà, Anna Díaz-Sáez, Francisco Camps, Marta Zorzano, Antonio Front Physiol Physiology Various external factors modulate the metabolic efficiency of mitochondria. This review focuses on the impact of the growth factor neuregulin and its ErbB receptors on mitochondria and their relationship with several physiopathological alterations. Neuregulin is involved in the differentiation of heart, skeletal muscle, and the neuronal system, among others; and its deficiency is deleterious for the health. Information gathered over the last two decades suggests that neuregulin plays a key role in regulating the mitochondrial oxidative machinery, which sustains cell survival and insulin sensitivity. Frontiers Media S.A. 2020-06-23 /pmc/articles/PMC7324780/ /pubmed/32655416 http://dx.doi.org/10.3389/fphys.2020.00696 Text en Copyright © 2020 Gumà, Díaz-Sáez, Camps and Zorzano. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Gumà, Anna
Díaz-Sáez, Francisco
Camps, Marta
Zorzano, Antonio
Neuregulin, an Effector on Mitochondria Metabolism That Preserves Insulin Sensitivity
title Neuregulin, an Effector on Mitochondria Metabolism That Preserves Insulin Sensitivity
title_full Neuregulin, an Effector on Mitochondria Metabolism That Preserves Insulin Sensitivity
title_fullStr Neuregulin, an Effector on Mitochondria Metabolism That Preserves Insulin Sensitivity
title_full_unstemmed Neuregulin, an Effector on Mitochondria Metabolism That Preserves Insulin Sensitivity
title_short Neuregulin, an Effector on Mitochondria Metabolism That Preserves Insulin Sensitivity
title_sort neuregulin, an effector on mitochondria metabolism that preserves insulin sensitivity
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324780/
https://www.ncbi.nlm.nih.gov/pubmed/32655416
http://dx.doi.org/10.3389/fphys.2020.00696
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