Molecular Basis of S100A1 Activation and Target Regulation Within Physiological Cytosolic Ca(2+) Levels

The S100A1 protein regulates cardiomyocyte function through its binding of calcium (Ca(2+)) and target proteins, including titin, SERCA, and RyR. S100A1 presents two Ca(2+) binding domains, a high-affinity canonical EF-hand (cEF) and a low-affinity pseudo EF-hand (pEF), that control S100A1 activatio...

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Detalles Bibliográficos
Autores principales: Sun, Bin, Kekenes-Huskey, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324869/
https://www.ncbi.nlm.nih.gov/pubmed/32656226
http://dx.doi.org/10.3389/fmolb.2020.00077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324869/
https://www.ncbi.nlm.nih.gov/pubmed/32656226
http://dx.doi.org/10.3389/fmolb.2020.00077

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