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Molecular Basis of S100A1 Activation and Target Regulation Within Physiological Cytosolic Ca(2+) Levels
The S100A1 protein regulates cardiomyocyte function through its binding of calcium (Ca(2+)) and target proteins, including titin, SERCA, and RyR. S100A1 presents two Ca(2+) binding domains, a high-affinity canonical EF-hand (cEF) and a low-affinity pseudo EF-hand (pEF), that control S100A1 activatio...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324869/ https://www.ncbi.nlm.nih.gov/pubmed/32656226 http://dx.doi.org/10.3389/fmolb.2020.00077 |