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Discovery of a Selective 6-Hydroxy-1, 4-Diazepan-2-one Containing Butyrylcholinesterase Inhibitor by Virtual Screening and MM-GBSA Rescoring

Alzheimer disease (AD) is the most common form of dementia characterized by the loss of cognitive abilities through the death of central neuronal cells. In this study, structure-based virtual screens of 2 central nervous system-targeted libraries followed by molecular mechanics/generalized born surf...

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Detalles Bibliográficos
Autores principales:	Zhou, You, Hu, Yanyu, Lu, Xin, Yang, Hongyu, Li, Qihang, Du, Chenxi, Chen, Yao, Hong, Kwon Ho, Sun, Haopeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2020
Materias:	Nanotechnology and Microtechnology in Drug Delivery Systems
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324897/ https://www.ncbi.nlm.nih.gov/pubmed/32636723 http://dx.doi.org/10.1177/1559325820938526

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