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Alterations of the Whole Cerebral Blood Flow in Patients With Different Total Cerebral Small Vessel Disease Burden

BACKGROUND: Cerebral small vessel disease (CSVD) is a common age-related vascular disease of the brain associated with slowly accumulating tissue damage. At present, total CSVD burden score is a commonly used method to evaluate the severity of the disease. PURPOSE: To observe whether global and regi...

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Autores principales: Yu, Chunyan, Lu, Weizhao, Qiu, Jianfeng, Wang, Feng, Li, Jinglei, Wang, Liru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324936/
https://www.ncbi.nlm.nih.gov/pubmed/32655393
http://dx.doi.org/10.3389/fnagi.2020.00175
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author Yu, Chunyan
Lu, Weizhao
Qiu, Jianfeng
Wang, Feng
Li, Jinglei
Wang, Liru
author_facet Yu, Chunyan
Lu, Weizhao
Qiu, Jianfeng
Wang, Feng
Li, Jinglei
Wang, Liru
author_sort Yu, Chunyan
collection PubMed
description BACKGROUND: Cerebral small vessel disease (CSVD) is a common age-related vascular disease of the brain associated with slowly accumulating tissue damage. At present, total CSVD burden score is a commonly used method to evaluate the severity of the disease. PURPOSE: To observe whether global and regional cerebral perfusion is related to total CSVD score and to explore global and regional cerebral blood flow (CBF) changes in patients with different degrees of CSVD. METHODS: We collected 130 subjects with different total burden score of CSVD (0 point: 33 subjects, 1 point: 39 subjects, 2 points: 24 subjects, 3 points: 24 subjects, 4 points: 10 subjects). Total CSVD burden score was evaluated by clinically routine sequences (T2WI, T2-FLAIR, T1WI, DWI, and SWAN sequence). Global and regional CBF were calculated and correlation analysis was used to investigate the relationship between total CSVD score and CBF of the whole brain and several brain regions. RESULTS: The analysis results showed that there was a negative correlation between total CSVD burden score and global CBF (r = −0.33, p = 0.001). Total CSVD burden score also had moderately negative correlations with CBF of almost all the brain regions. CONCLUSION: CSVD is a disease that affects the whole brain. With the increase of total CSVD burden score, the global and regional CBF decreased. The CSVD total burden score could be used to evaluate the overall condition of brain perfusion.
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spelling pubmed-73249362020-07-10 Alterations of the Whole Cerebral Blood Flow in Patients With Different Total Cerebral Small Vessel Disease Burden Yu, Chunyan Lu, Weizhao Qiu, Jianfeng Wang, Feng Li, Jinglei Wang, Liru Front Aging Neurosci Neuroscience BACKGROUND: Cerebral small vessel disease (CSVD) is a common age-related vascular disease of the brain associated with slowly accumulating tissue damage. At present, total CSVD burden score is a commonly used method to evaluate the severity of the disease. PURPOSE: To observe whether global and regional cerebral perfusion is related to total CSVD score and to explore global and regional cerebral blood flow (CBF) changes in patients with different degrees of CSVD. METHODS: We collected 130 subjects with different total burden score of CSVD (0 point: 33 subjects, 1 point: 39 subjects, 2 points: 24 subjects, 3 points: 24 subjects, 4 points: 10 subjects). Total CSVD burden score was evaluated by clinically routine sequences (T2WI, T2-FLAIR, T1WI, DWI, and SWAN sequence). Global and regional CBF were calculated and correlation analysis was used to investigate the relationship between total CSVD score and CBF of the whole brain and several brain regions. RESULTS: The analysis results showed that there was a negative correlation between total CSVD burden score and global CBF (r = −0.33, p = 0.001). Total CSVD burden score also had moderately negative correlations with CBF of almost all the brain regions. CONCLUSION: CSVD is a disease that affects the whole brain. With the increase of total CSVD burden score, the global and regional CBF decreased. The CSVD total burden score could be used to evaluate the overall condition of brain perfusion. Frontiers Media S.A. 2020-06-23 /pmc/articles/PMC7324936/ /pubmed/32655393 http://dx.doi.org/10.3389/fnagi.2020.00175 Text en Copyright © 2020 Yu, Lu, Qiu, Wang, Li and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Yu, Chunyan
Lu, Weizhao
Qiu, Jianfeng
Wang, Feng
Li, Jinglei
Wang, Liru
Alterations of the Whole Cerebral Blood Flow in Patients With Different Total Cerebral Small Vessel Disease Burden
title Alterations of the Whole Cerebral Blood Flow in Patients With Different Total Cerebral Small Vessel Disease Burden
title_full Alterations of the Whole Cerebral Blood Flow in Patients With Different Total Cerebral Small Vessel Disease Burden
title_fullStr Alterations of the Whole Cerebral Blood Flow in Patients With Different Total Cerebral Small Vessel Disease Burden
title_full_unstemmed Alterations of the Whole Cerebral Blood Flow in Patients With Different Total Cerebral Small Vessel Disease Burden
title_short Alterations of the Whole Cerebral Blood Flow in Patients With Different Total Cerebral Small Vessel Disease Burden
title_sort alterations of the whole cerebral blood flow in patients with different total cerebral small vessel disease burden
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324936/
https://www.ncbi.nlm.nih.gov/pubmed/32655393
http://dx.doi.org/10.3389/fnagi.2020.00175
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