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Predicting the Trajectory of Any COVID19 Epidemic From the Best Straight Line

A pipeline involving data acquisition, curation, carefully chosen graphs and mathematical models, allows analysis of COVID-19 outbreaks at 3,546 locations world-wide (all countries plus smaller administrative divisions with data available). Comparison of locations with over 50 deaths shows all outbr...

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Detalles Bibliográficos
Autores principales: Levitt, Michael, Scaiewicz, Andrea, Zonta, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325180/
https://www.ncbi.nlm.nih.gov/pubmed/32607515
http://dx.doi.org/10.1101/2020.06.26.20140814
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author Levitt, Michael
Scaiewicz, Andrea
Zonta, Francesco
author_facet Levitt, Michael
Scaiewicz, Andrea
Zonta, Francesco
author_sort Levitt, Michael
collection PubMed
description A pipeline involving data acquisition, curation, carefully chosen graphs and mathematical models, allows analysis of COVID-19 outbreaks at 3,546 locations world-wide (all countries plus smaller administrative divisions with data available). Comparison of locations with over 50 deaths shows all outbreaks have a common feature: H(t) defined as log(e)(X(t)/X(t-1)) decreases linearly on a log scale, where X(t) is the total number of Cases or Deaths on day, t (we use ln for log(e)). The downward slopes vary by about a factor of three with time constants (1/slope) of between 1 and 3 weeks; this suggests it may be possible to predict when an outbreak will end. Is it possible to go beyond this and perform early prediction of the outcome in terms of the eventual plateau number of total confirmed cases or deaths? We test this hypothesis by showing that the trajectory of cases or deaths in any outbreak can be converted into a straight line. Specifically Y(t) ≡ −ln(ln(N / X(t)), is a straight line for the correct plateau value N, which is determined by a new method, Best-Line Fitting (BLF). BLF involves a straight-line facilitation extrapolation needed for prediction; it is blindingly fast and amenable to optimization. We find that in some locations that entire trajectory can be predicted early, whereas others take longer to follow this simple functional form. Fortunately, BLF distinguishes predictions that are likely to be correct in that they show a stable plateau of total cases or death (N value). We apply BLF to locations that seem close to a stable predicted N value and then forecast the outcome at some locations that are still growing wildly. Our accompanying web-site will be updated frequently and provide all graphs and data described here.
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spelling pubmed-73251802020-06-30 Predicting the Trajectory of Any COVID19 Epidemic From the Best Straight Line Levitt, Michael Scaiewicz, Andrea Zonta, Francesco medRxiv Article A pipeline involving data acquisition, curation, carefully chosen graphs and mathematical models, allows analysis of COVID-19 outbreaks at 3,546 locations world-wide (all countries plus smaller administrative divisions with data available). Comparison of locations with over 50 deaths shows all outbreaks have a common feature: H(t) defined as log(e)(X(t)/X(t-1)) decreases linearly on a log scale, where X(t) is the total number of Cases or Deaths on day, t (we use ln for log(e)). The downward slopes vary by about a factor of three with time constants (1/slope) of between 1 and 3 weeks; this suggests it may be possible to predict when an outbreak will end. Is it possible to go beyond this and perform early prediction of the outcome in terms of the eventual plateau number of total confirmed cases or deaths? We test this hypothesis by showing that the trajectory of cases or deaths in any outbreak can be converted into a straight line. Specifically Y(t) ≡ −ln(ln(N / X(t)), is a straight line for the correct plateau value N, which is determined by a new method, Best-Line Fitting (BLF). BLF involves a straight-line facilitation extrapolation needed for prediction; it is blindingly fast and amenable to optimization. We find that in some locations that entire trajectory can be predicted early, whereas others take longer to follow this simple functional form. Fortunately, BLF distinguishes predictions that are likely to be correct in that they show a stable plateau of total cases or death (N value). We apply BLF to locations that seem close to a stable predicted N value and then forecast the outcome at some locations that are still growing wildly. Our accompanying web-site will be updated frequently and provide all graphs and data described here. Cold Spring Harbor Laboratory 2020-06-30 /pmc/articles/PMC7325180/ /pubmed/32607515 http://dx.doi.org/10.1101/2020.06.26.20140814 Text en http://creativecommons.org/licenses/by-nd/4.0/It is made available under a CC-BY-ND 4.0 International license (http://creativecommons.org/licenses/by-nd/4.0/) .
spellingShingle Article
Levitt, Michael
Scaiewicz, Andrea
Zonta, Francesco
Predicting the Trajectory of Any COVID19 Epidemic From the Best Straight Line
title Predicting the Trajectory of Any COVID19 Epidemic From the Best Straight Line
title_full Predicting the Trajectory of Any COVID19 Epidemic From the Best Straight Line
title_fullStr Predicting the Trajectory of Any COVID19 Epidemic From the Best Straight Line
title_full_unstemmed Predicting the Trajectory of Any COVID19 Epidemic From the Best Straight Line
title_short Predicting the Trajectory of Any COVID19 Epidemic From the Best Straight Line
title_sort predicting the trajectory of any covid19 epidemic from the best straight line
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325180/
https://www.ncbi.nlm.nih.gov/pubmed/32607515
http://dx.doi.org/10.1101/2020.06.26.20140814
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