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Human iPSCs derived astrocytes rescue rotenone-induced mitochondrial dysfunction and dopaminergic neurodegeneration in vitro by donating functional mitochondria

BACKGROUND: Parkinson’s disease (PD) is one of the neurodegeneration diseases characterized by the gradual loss of dopaminergic (DA) neurons in the substantia nigra region of the brain. Substantial evidence indicates that at the cellular level mitochondrial dysfunction is a key factor leading to pat...

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Detalles Bibliográficos
Autores principales:	Cheng, Xiao-Yu, Biswas, Sangita, Li, Juan, Mao, Cheng-Jie, Chechneva, Olga, Chen, Jing, Li, Kai, Li, Jiao, Zhang, Jin-Ru, Liu, Chun-Feng, Deng, Wen-Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325238/ https://www.ncbi.nlm.nih.gov/pubmed/32345341 http://dx.doi.org/10.1186/s40035-020-00190-6

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