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Diagnostic Pearls and Clinical Implications of Prekallikrein Deficiency
Prekallikrein (PK) deficiency is extremely rare, and manifestations are not well characterized due to a small number of cases reported and the lack of scientific clarity about its role in clot formation in vivo. Here, we report a case of a 64-year-old male, with no known history of abnormal bleeding...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325379/ https://www.ncbi.nlm.nih.gov/pubmed/32617222 http://dx.doi.org/10.7759/cureus.8349 |
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author | Yasin, Hassaan Jamil, Muhammad Omer Williams, III, Lance A |
author_facet | Yasin, Hassaan Jamil, Muhammad Omer Williams, III, Lance A |
author_sort | Yasin, Hassaan |
collection | PubMed |
description | Prekallikrein (PK) deficiency is extremely rare, and manifestations are not well characterized due to a small number of cases reported and the lack of scientific clarity about its role in clot formation in vivo. Here, we report a case of a 64-year-old male, with no known history of abnormal bleeding, who scheduled to undergo deep brain stimulator placement for control of his Parkinson’s disease. During pre-procedure testing, activated partial thromboplastin time (PTT) was found to be prolonged at 146 seconds. Mixing studies were suggestive of a coagulation factor deficiency. His PTT characteristically became shorter with prolonged incubation, providing a clue at testing for PK levels, which were found to be severely low. He, subsequently, underwent surgery without any complications. Our case further highlights the clinical pearls for diagnosis and further endorses that these patients can safely undergo surgical procedures without the need for plasma transfusions or factor concentrate usage. |
format | Online Article Text |
id | pubmed-7325379 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-73253792020-07-01 Diagnostic Pearls and Clinical Implications of Prekallikrein Deficiency Yasin, Hassaan Jamil, Muhammad Omer Williams, III, Lance A Cureus Internal Medicine Prekallikrein (PK) deficiency is extremely rare, and manifestations are not well characterized due to a small number of cases reported and the lack of scientific clarity about its role in clot formation in vivo. Here, we report a case of a 64-year-old male, with no known history of abnormal bleeding, who scheduled to undergo deep brain stimulator placement for control of his Parkinson’s disease. During pre-procedure testing, activated partial thromboplastin time (PTT) was found to be prolonged at 146 seconds. Mixing studies were suggestive of a coagulation factor deficiency. His PTT characteristically became shorter with prolonged incubation, providing a clue at testing for PK levels, which were found to be severely low. He, subsequently, underwent surgery without any complications. Our case further highlights the clinical pearls for diagnosis and further endorses that these patients can safely undergo surgical procedures without the need for plasma transfusions or factor concentrate usage. Cureus 2020-05-29 /pmc/articles/PMC7325379/ /pubmed/32617222 http://dx.doi.org/10.7759/cureus.8349 Text en Copyright © 2020, Yasin et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Yasin, Hassaan Jamil, Muhammad Omer Williams, III, Lance A Diagnostic Pearls and Clinical Implications of Prekallikrein Deficiency |
title | Diagnostic Pearls and Clinical Implications of Prekallikrein Deficiency |
title_full | Diagnostic Pearls and Clinical Implications of Prekallikrein Deficiency |
title_fullStr | Diagnostic Pearls and Clinical Implications of Prekallikrein Deficiency |
title_full_unstemmed | Diagnostic Pearls and Clinical Implications of Prekallikrein Deficiency |
title_short | Diagnostic Pearls and Clinical Implications of Prekallikrein Deficiency |
title_sort | diagnostic pearls and clinical implications of prekallikrein deficiency |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325379/ https://www.ncbi.nlm.nih.gov/pubmed/32617222 http://dx.doi.org/10.7759/cureus.8349 |
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