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Association between the 2D:4D ratio and schizophrenia

OBJECTIVE: To investigate the potential association between the ratio of the second digit length to the fourth digit length (2D:4D) and schizophrenia, to provide evidence regarding the pathogenesis of schizophrenia. METHODS: In this study, we enrolled 843 patients with schizophrenia (387 men and 456...

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Autores principales: Han, Yuanyuan, Deng, Wei, Lei, Wei, Lin, Yin, Li, Yinfei, Li, Mingli, Li, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325465/
https://www.ncbi.nlm.nih.gov/pubmed/32589860
http://dx.doi.org/10.1177/0300060520929148
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author Han, Yuanyuan
Deng, Wei
Lei, Wei
Lin, Yin
Li, Yinfei
Li, Mingli
Li, Tao
author_facet Han, Yuanyuan
Deng, Wei
Lei, Wei
Lin, Yin
Li, Yinfei
Li, Mingli
Li, Tao
author_sort Han, Yuanyuan
collection PubMed
description OBJECTIVE: To investigate the potential association between the ratio of the second digit length to the fourth digit length (2D:4D) and schizophrenia, to provide evidence regarding the pathogenesis of schizophrenia. METHODS: In this study, we enrolled 843 patients with schizophrenia (387 men and 456 women), all of whom met the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV), and 1050 normal healthy controls (477 men and 573 women). The digit lengths of both hands were measured in all subjects and the 2D:4D ratio was analyzed. RESULTS: In the healthy controls, the 2D:4D ratio was sexually dimorphic, with a larger value in women than in men. In addition, the 2D:4D ratio in the schizophrenia patients was significantly larger than in the healthy controls. The 2D:4D ratio of the right hand was more sexually dimorphic than the left hand. Furthermore, the difference in 2D:4D ratios between the male patients and male controls was significantly larger than in their female counterparts. CONCLUSIONS: By analyzing the 2D:4D ratio and considering alternative factors related to schizophrenia, our findings support the hypothesis that there are abnormal cerebral conditions in schizophrenia patients.
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spelling pubmed-73254652020-07-08 Association between the 2D:4D ratio and schizophrenia Han, Yuanyuan Deng, Wei Lei, Wei Lin, Yin Li, Yinfei Li, Mingli Li, Tao J Int Med Res Prospective Clinical Research Report OBJECTIVE: To investigate the potential association between the ratio of the second digit length to the fourth digit length (2D:4D) and schizophrenia, to provide evidence regarding the pathogenesis of schizophrenia. METHODS: In this study, we enrolled 843 patients with schizophrenia (387 men and 456 women), all of whom met the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV), and 1050 normal healthy controls (477 men and 573 women). The digit lengths of both hands were measured in all subjects and the 2D:4D ratio was analyzed. RESULTS: In the healthy controls, the 2D:4D ratio was sexually dimorphic, with a larger value in women than in men. In addition, the 2D:4D ratio in the schizophrenia patients was significantly larger than in the healthy controls. The 2D:4D ratio of the right hand was more sexually dimorphic than the left hand. Furthermore, the difference in 2D:4D ratios between the male patients and male controls was significantly larger than in their female counterparts. CONCLUSIONS: By analyzing the 2D:4D ratio and considering alternative factors related to schizophrenia, our findings support the hypothesis that there are abnormal cerebral conditions in schizophrenia patients. SAGE Publications 2020-06-26 /pmc/articles/PMC7325465/ /pubmed/32589860 http://dx.doi.org/10.1177/0300060520929148 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Prospective Clinical Research Report
Han, Yuanyuan
Deng, Wei
Lei, Wei
Lin, Yin
Li, Yinfei
Li, Mingli
Li, Tao
Association between the 2D:4D ratio and schizophrenia
title Association between the 2D:4D ratio and schizophrenia
title_full Association between the 2D:4D ratio and schizophrenia
title_fullStr Association between the 2D:4D ratio and schizophrenia
title_full_unstemmed Association between the 2D:4D ratio and schizophrenia
title_short Association between the 2D:4D ratio and schizophrenia
title_sort association between the 2d:4d ratio and schizophrenia
topic Prospective Clinical Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325465/
https://www.ncbi.nlm.nih.gov/pubmed/32589860
http://dx.doi.org/10.1177/0300060520929148
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