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Community memory screening as a strategy for recruiting older adults into Alzheimer’s disease research

BACKGROUND: Growing awareness of Alzheimer’s disease (AD) has prompted a demand for quick and effective ways to screen for memory loss and cognitive decline in large numbers of individuals in the community. Periodic Memory Screening Day events provide free, brief cognitive screening aimed at those 6...

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Autores principales: Peavy, Guerry M., Jenkins, Cecily W., Little, Emily A., Gigliotti, Christina, Calcetas, Amanda, Edland, Steven D., Brewer, James B., Galasko, Douglas, Salmon, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325657/
https://www.ncbi.nlm.nih.gov/pubmed/32605603
http://dx.doi.org/10.1186/s13195-020-00643-0
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author Peavy, Guerry M.
Jenkins, Cecily W.
Little, Emily A.
Gigliotti, Christina
Calcetas, Amanda
Edland, Steven D.
Brewer, James B.
Galasko, Douglas
Salmon, David P.
author_facet Peavy, Guerry M.
Jenkins, Cecily W.
Little, Emily A.
Gigliotti, Christina
Calcetas, Amanda
Edland, Steven D.
Brewer, James B.
Galasko, Douglas
Salmon, David P.
author_sort Peavy, Guerry M.
collection PubMed
description BACKGROUND: Growing awareness of Alzheimer’s disease (AD) has prompted a demand for quick and effective ways to screen for memory loss and cognitive decline in large numbers of individuals in the community. Periodic Memory Screening Day events provide free, brief cognitive screening aimed at those 65 years and older, and can serve as an opportunity to gauge participants’ attitudes towards AD research and recruit them into ongoing research projects. METHODS: Over 6 single-day events in 2 years, more than 574 individuals were individually screened using the MoCA and a story recall task (immediate and delayed), given feedback about their performance, and introduced to AD research and opportunities to participate. RESULTS: Screening classified 297 individuals (52.0%) as having “No Decline,” 192 (33.6%) as “Possible decline,” and 82 (14.4%) as “Likely decline.” Those with “Likely decline” were older and less educated, had more memory concerns, were more likely to be men, and were less likely to have a positive family history of dementia than those with “No Decline.” Subsequent validation of screening procedures against a full clinical evaluation showed 72% classification accuracy with a skew towards over-calling Possible and Likely decline and thereby guiding questionable individuals to a more thorough evaluation. Of those screened, 378 (66%) agreed to additional research and consented to being listed in a research registry, and a majority (70–85%) of those consenting reported they were amenable to various AD research procedures including lumbar puncture, MRI, and autopsy. Overall, 19.1% of those screened met inclusion criteria for ongoing studies and were successfully recruited into AD research. CONCLUSIONS: Conducting a few concentrated community memory screening events each year may help meet the public’s demand for brief assessment of memory concerns and can be a relatively effective and efficient recruitment strategy for AD research.
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spelling pubmed-73256572020-07-01 Community memory screening as a strategy for recruiting older adults into Alzheimer’s disease research Peavy, Guerry M. Jenkins, Cecily W. Little, Emily A. Gigliotti, Christina Calcetas, Amanda Edland, Steven D. Brewer, James B. Galasko, Douglas Salmon, David P. Alzheimers Res Ther Research BACKGROUND: Growing awareness of Alzheimer’s disease (AD) has prompted a demand for quick and effective ways to screen for memory loss and cognitive decline in large numbers of individuals in the community. Periodic Memory Screening Day events provide free, brief cognitive screening aimed at those 65 years and older, and can serve as an opportunity to gauge participants’ attitudes towards AD research and recruit them into ongoing research projects. METHODS: Over 6 single-day events in 2 years, more than 574 individuals were individually screened using the MoCA and a story recall task (immediate and delayed), given feedback about their performance, and introduced to AD research and opportunities to participate. RESULTS: Screening classified 297 individuals (52.0%) as having “No Decline,” 192 (33.6%) as “Possible decline,” and 82 (14.4%) as “Likely decline.” Those with “Likely decline” were older and less educated, had more memory concerns, were more likely to be men, and were less likely to have a positive family history of dementia than those with “No Decline.” Subsequent validation of screening procedures against a full clinical evaluation showed 72% classification accuracy with a skew towards over-calling Possible and Likely decline and thereby guiding questionable individuals to a more thorough evaluation. Of those screened, 378 (66%) agreed to additional research and consented to being listed in a research registry, and a majority (70–85%) of those consenting reported they were amenable to various AD research procedures including lumbar puncture, MRI, and autopsy. Overall, 19.1% of those screened met inclusion criteria for ongoing studies and were successfully recruited into AD research. CONCLUSIONS: Conducting a few concentrated community memory screening events each year may help meet the public’s demand for brief assessment of memory concerns and can be a relatively effective and efficient recruitment strategy for AD research. BioMed Central 2020-06-30 /pmc/articles/PMC7325657/ /pubmed/32605603 http://dx.doi.org/10.1186/s13195-020-00643-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Peavy, Guerry M.
Jenkins, Cecily W.
Little, Emily A.
Gigliotti, Christina
Calcetas, Amanda
Edland, Steven D.
Brewer, James B.
Galasko, Douglas
Salmon, David P.
Community memory screening as a strategy for recruiting older adults into Alzheimer’s disease research
title Community memory screening as a strategy for recruiting older adults into Alzheimer’s disease research
title_full Community memory screening as a strategy for recruiting older adults into Alzheimer’s disease research
title_fullStr Community memory screening as a strategy for recruiting older adults into Alzheimer’s disease research
title_full_unstemmed Community memory screening as a strategy for recruiting older adults into Alzheimer’s disease research
title_short Community memory screening as a strategy for recruiting older adults into Alzheimer’s disease research
title_sort community memory screening as a strategy for recruiting older adults into alzheimer’s disease research
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325657/
https://www.ncbi.nlm.nih.gov/pubmed/32605603
http://dx.doi.org/10.1186/s13195-020-00643-0
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