Role of MIF Cytokine/CD74 Receptor Pathway in Protecting Against Injury and Promoting Repair

Wound healing after an injury is essential for life. An in-depth understanding of the healing process is necessary to ultimately improve the currently limited treatment options for patients suffering as a result of damage to various organs and tissues. Injuries, even the most minor, trigger an infla...

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Detalles Bibliográficos
Autores principales: Farr, Laura, Ghosh, Swagata, Moonah, Shannon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325688/
https://www.ncbi.nlm.nih.gov/pubmed/32655566
http://dx.doi.org/10.3389/fimmu.2020.01273
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author Farr, Laura
Ghosh, Swagata
Moonah, Shannon
author_facet Farr, Laura
Ghosh, Swagata
Moonah, Shannon
author_sort Farr, Laura
collection PubMed
description Wound healing after an injury is essential for life. An in-depth understanding of the healing process is necessary to ultimately improve the currently limited treatment options for patients suffering as a result of damage to various organs and tissues. Injuries, even the most minor, trigger an inflammatory response that protects the host and activates repair pathways. In recent years, substantial progress has been made in delineating the mechanisms by which inflammatory cytokines and their receptors facilitate tissue repair and regeneration. This mini review focuses on emerging literature on the role of the cytokine macrophage migration inhibitory factor (MIF) and its cell membrane receptor CD74, in protecting against injury and promoting healing in different parts of the body.
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spelling pubmed-73256882020-07-09 Role of MIF Cytokine/CD74 Receptor Pathway in Protecting Against Injury and Promoting Repair Farr, Laura Ghosh, Swagata Moonah, Shannon Front Immunol Immunology Wound healing after an injury is essential for life. An in-depth understanding of the healing process is necessary to ultimately improve the currently limited treatment options for patients suffering as a result of damage to various organs and tissues. Injuries, even the most minor, trigger an inflammatory response that protects the host and activates repair pathways. In recent years, substantial progress has been made in delineating the mechanisms by which inflammatory cytokines and their receptors facilitate tissue repair and regeneration. This mini review focuses on emerging literature on the role of the cytokine macrophage migration inhibitory factor (MIF) and its cell membrane receptor CD74, in protecting against injury and promoting healing in different parts of the body. Frontiers Media S.A. 2020-06-23 /pmc/articles/PMC7325688/ /pubmed/32655566 http://dx.doi.org/10.3389/fimmu.2020.01273 Text en Copyright © 2020 Farr, Ghosh and Moonah. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Farr, Laura
Ghosh, Swagata
Moonah, Shannon
Role of MIF Cytokine/CD74 Receptor Pathway in Protecting Against Injury and Promoting Repair
title Role of MIF Cytokine/CD74 Receptor Pathway in Protecting Against Injury and Promoting Repair
title_full Role of MIF Cytokine/CD74 Receptor Pathway in Protecting Against Injury and Promoting Repair
title_fullStr Role of MIF Cytokine/CD74 Receptor Pathway in Protecting Against Injury and Promoting Repair
title_full_unstemmed Role of MIF Cytokine/CD74 Receptor Pathway in Protecting Against Injury and Promoting Repair
title_short Role of MIF Cytokine/CD74 Receptor Pathway in Protecting Against Injury and Promoting Repair
title_sort role of mif cytokine/cd74 receptor pathway in protecting against injury and promoting repair
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325688/
https://www.ncbi.nlm.nih.gov/pubmed/32655566
http://dx.doi.org/10.3389/fimmu.2020.01273
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