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Synaptic Recruitment Enhances Gap Termination Responses in Auditory Cortex

The ability to detect short gaps in noise is an important tool for assessing the temporal resolution in the auditory cortex. However, the mere existence of responses to temporal gaps bounded by two short broadband markers is surprising, because of the expected short-term suppression that is prevalen...

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Detalles Bibliográficos
Autores principales: Awwad, Bshara, Jankowski, Maciej M, Nelken, Israel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325714/
https://www.ncbi.nlm.nih.gov/pubmed/32147725
http://dx.doi.org/10.1093/cercor/bhaa044
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author Awwad, Bshara
Jankowski, Maciej M
Nelken, Israel
author_facet Awwad, Bshara
Jankowski, Maciej M
Nelken, Israel
author_sort Awwad, Bshara
collection PubMed
description The ability to detect short gaps in noise is an important tool for assessing the temporal resolution in the auditory cortex. However, the mere existence of responses to temporal gaps bounded by two short broadband markers is surprising, because of the expected short-term suppression that is prevalent in auditory cortex. Here, we used in-vivo intracellular recordings in anesthetized rats to dissect the synaptic mechanisms that underlie gap-related responses. When a gap is bounded by two short markers, a gap termination response was evoked by the onset of the second marker with minimal contribution from the offset of the first marker. Importantly, we show that the gap termination response was driven by a different (potentially partially overlapping) synaptic population than that underlying the onset response to the first marker. This recruitment of additional synaptic resources is a novel mechanism contributing to the important perceptual task of gap detection.
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spelling pubmed-73257142020-07-13 Synaptic Recruitment Enhances Gap Termination Responses in Auditory Cortex Awwad, Bshara Jankowski, Maciej M Nelken, Israel Cereb Cortex Original Article The ability to detect short gaps in noise is an important tool for assessing the temporal resolution in the auditory cortex. However, the mere existence of responses to temporal gaps bounded by two short broadband markers is surprising, because of the expected short-term suppression that is prevalent in auditory cortex. Here, we used in-vivo intracellular recordings in anesthetized rats to dissect the synaptic mechanisms that underlie gap-related responses. When a gap is bounded by two short markers, a gap termination response was evoked by the onset of the second marker with minimal contribution from the offset of the first marker. Importantly, we show that the gap termination response was driven by a different (potentially partially overlapping) synaptic population than that underlying the onset response to the first marker. This recruitment of additional synaptic resources is a novel mechanism contributing to the important perceptual task of gap detection. Oxford University Press 2020-06 2020-03-07 /pmc/articles/PMC7325714/ /pubmed/32147725 http://dx.doi.org/10.1093/cercor/bhaa044 Text en © The Author(s) 2020. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Article
Awwad, Bshara
Jankowski, Maciej M
Nelken, Israel
Synaptic Recruitment Enhances Gap Termination Responses in Auditory Cortex
title Synaptic Recruitment Enhances Gap Termination Responses in Auditory Cortex
title_full Synaptic Recruitment Enhances Gap Termination Responses in Auditory Cortex
title_fullStr Synaptic Recruitment Enhances Gap Termination Responses in Auditory Cortex
title_full_unstemmed Synaptic Recruitment Enhances Gap Termination Responses in Auditory Cortex
title_short Synaptic Recruitment Enhances Gap Termination Responses in Auditory Cortex
title_sort synaptic recruitment enhances gap termination responses in auditory cortex
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325714/
https://www.ncbi.nlm.nih.gov/pubmed/32147725
http://dx.doi.org/10.1093/cercor/bhaa044
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