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Presenilin 1 increases association with synaptotagmin 1 during normal aging
Presenilin 1 (PS1), the catalytic component of gamma secretase, associates with synaptotagmin 1 (Syt-1). This interaction is decreased in the brains of patients with sporadic Alzheimer’s disease. However, it remains unclear how this interaction changes during normal aging. Because aging is a risk fa...
Autores principales: | Keller, Laura J., Sekula, Nicole M., Svirsky, Sarah, Maesako, Masato, Zoltowska, Katarzyna M., Berezovska, Oksana |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325863/ https://www.ncbi.nlm.nih.gov/pubmed/31864759 http://dx.doi.org/10.1016/j.neurobiolaging.2019.10.006 |
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