The Characterization of Two-Component System PmrA/PmrB in Cronobacter sakazakii

Cronobacter sakazakii is an opportunistic Gram-negative pathogen that could cause meningitis and necrotizing enterocolitis. Several Gram-negative bacteria use the PmrA/PmrB system to sense and adapt to environmental change by resistance to cationic antimicrobial peptides of host immune systems. The...

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Detalles Bibliográficos
Autores principales: Hua, Jingjing, Jia, Xiangyin, Zhang, Liang, Li, Yanyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326031/
https://www.ncbi.nlm.nih.gov/pubmed/32655500
http://dx.doi.org/10.3389/fmicb.2020.00903
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author Hua, Jingjing
Jia, Xiangyin
Zhang, Liang
Li, Yanyan
author_facet Hua, Jingjing
Jia, Xiangyin
Zhang, Liang
Li, Yanyan
author_sort Hua, Jingjing
collection PubMed
description Cronobacter sakazakii is an opportunistic Gram-negative pathogen that could cause meningitis and necrotizing enterocolitis. Several Gram-negative bacteria use the PmrA/PmrB system to sense and adapt to environmental change by resistance to cationic antimicrobial peptides of host immune systems. The PmrA/PmrB two-component system regulates several genes to modify LPS structure in the bacterial outer membrane. The role of PmrA/PmrB of C. sakazakii has been studied within the current study. The results suggest that PmrA/PmrB plays a crucial role in modifying LPS structure, cationic antimicrobial peptide susceptibility, cell membrane permeability and hydrophobicity, and invading macrophage.
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spelling pubmed-73260312020-07-09 The Characterization of Two-Component System PmrA/PmrB in Cronobacter sakazakii Hua, Jingjing Jia, Xiangyin Zhang, Liang Li, Yanyan Front Microbiol Microbiology Cronobacter sakazakii is an opportunistic Gram-negative pathogen that could cause meningitis and necrotizing enterocolitis. Several Gram-negative bacteria use the PmrA/PmrB system to sense and adapt to environmental change by resistance to cationic antimicrobial peptides of host immune systems. The PmrA/PmrB two-component system regulates several genes to modify LPS structure in the bacterial outer membrane. The role of PmrA/PmrB of C. sakazakii has been studied within the current study. The results suggest that PmrA/PmrB plays a crucial role in modifying LPS structure, cationic antimicrobial peptide susceptibility, cell membrane permeability and hydrophobicity, and invading macrophage. Frontiers Media S.A. 2020-06-17 /pmc/articles/PMC7326031/ /pubmed/32655500 http://dx.doi.org/10.3389/fmicb.2020.00903 Text en Copyright © 2020 Hua, Jia, Zhang and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Hua, Jingjing
Jia, Xiangyin
Zhang, Liang
Li, Yanyan
The Characterization of Two-Component System PmrA/PmrB in Cronobacter sakazakii
title The Characterization of Two-Component System PmrA/PmrB in Cronobacter sakazakii
title_full The Characterization of Two-Component System PmrA/PmrB in Cronobacter sakazakii
title_fullStr The Characterization of Two-Component System PmrA/PmrB in Cronobacter sakazakii
title_full_unstemmed The Characterization of Two-Component System PmrA/PmrB in Cronobacter sakazakii
title_short The Characterization of Two-Component System PmrA/PmrB in Cronobacter sakazakii
title_sort characterization of two-component system pmra/pmrb in cronobacter sakazakii
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326031/
https://www.ncbi.nlm.nih.gov/pubmed/32655500
http://dx.doi.org/10.3389/fmicb.2020.00903
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