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Utilising animal models to evaluate oseltamivir efficacy against influenza A and B viruses with reduced in vitro susceptibility

The neuraminidase (NA) inhibitor (NAI) oseltamivir (OST) is the most widely used influenza antiviral drug. Several NA amino acid substitutions are reported to reduce viral susceptibility to OST in in vitro assays. However, whether there is a correlation between the level of reduction in susceptibili...

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Detalles Bibliográficos
Autores principales:	Farrukee, Rubaiyea, Tai, Celeste Ming-Kay, Oh, Ding Yuan, Anderson, Danielle E., Gunalan, Vithiagaran, Hibberd, Martin, Lau, Gary Yuk-Fai, Barr, Ian G., von Messling, Veronika, Maurer-Stroh, Sebastian, Hurt, Aeron C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326275/ https://www.ncbi.nlm.nih.gov/pubmed/32555740 http://dx.doi.org/10.1371/journal.ppat.1008592

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