mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis

Cancer cells display an increased plasticity in their lipid metabolism, which includes the conversion of palmitate to sapienate via the enzyme fatty acid desaturase 2 (FADS2). We find that FADS2 expression correlates with mammalian target of rapamycin (mTOR) signaling and sterol regulatory element-b...

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Detalles Bibliográficos
Autores principales: Triki, Mouna, Rinaldi, Gianmarco, Planque, Melanie, Broekaert, Dorien, Winkelkotte, Alina M., Maier, Carina R., Janaki Raman, Sudha, Vandekeere, Anke, Van Elsen, Joke, Orth, Martin F., Grünewald, Thomas G.P., Schulze, Almut, Fendt, Sarah-Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326293/
https://www.ncbi.nlm.nih.gov/pubmed/32579932
http://dx.doi.org/10.1016/j.celrep.2020.107806

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