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Endocrine disruption and obesity: A current review on environmental obesogens
Obesity represents an important public health concern because it substantially increases the risk of multiple chronic diseases and thereby contributing to a decline in both quality of life and life expectancy. Besides unhealthy diet, physical inactivity and genetic susceptibility, environmental poll...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Author(s). Published by Elsevier B.V.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326440/ http://dx.doi.org/10.1016/j.crgsc.2020.06.002 |
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author | Gupta, Radhika Kumar, Prashant Fahmi, Nighat Garg, Bhaskar Dutta, Sriparna Sachar, Shilpee Matharu, Avtar S. Vimaleswaran, Karani S. |
author_facet | Gupta, Radhika Kumar, Prashant Fahmi, Nighat Garg, Bhaskar Dutta, Sriparna Sachar, Shilpee Matharu, Avtar S. Vimaleswaran, Karani S. |
author_sort | Gupta, Radhika |
collection | PubMed |
description | Obesity represents an important public health concern because it substantially increases the risk of multiple chronic diseases and thereby contributing to a decline in both quality of life and life expectancy. Besides unhealthy diet, physical inactivity and genetic susceptibility, environmental pollutants also contribute to the rising prevalence of obesity epidemic. An environmental obesogen is defined as a chemical that can alter lipid homeostasis to promote adipogenesis and lipid accumulation whereas an endocrine disrupting chemical (EDC) is defined as a synthetic chemical that can interfere with the endocrine function and cause adverse health effects. Many obesogens are EDCs that interfere with normal endocrine regulation of metabolism, adipose tissue development and maintenance, appetite, weight and energy balance. An expanding body of scientific evidence from animal and epidemiological studies has begun to provide links between exposure to EDCs and obesity. Despite the significance of environmental obesogens in the pathogenesis of metabolic diseases, the contribution of synthetic chemical exposure to obesity epidemic remains largely unrecognised. Hence, the purpose of this review is to provide a current update on the evidences from animal and human studies on the role of fourteen environmental obesogens in obesity, a comprehensive view of the mechanisms of action of these obesogens and current green and sustainable chemistry strategies to overcome chemical exposure to prevent obesity. Designing of safer version of obesogens through green chemistry approaches requires a collaborative undertaking to evaluate the toxicity of endocrine disruptors using appropriate experimental methods, which will help in developing a new generation of inherently safer chemicals. |
format | Online Article Text |
id | pubmed-7326440 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Author(s). Published by Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73264402020-07-01 Endocrine disruption and obesity: A current review on environmental obesogens Gupta, Radhika Kumar, Prashant Fahmi, Nighat Garg, Bhaskar Dutta, Sriparna Sachar, Shilpee Matharu, Avtar S. Vimaleswaran, Karani S. Current Research in Green and Sustainable Chemistry Article Obesity represents an important public health concern because it substantially increases the risk of multiple chronic diseases and thereby contributing to a decline in both quality of life and life expectancy. Besides unhealthy diet, physical inactivity and genetic susceptibility, environmental pollutants also contribute to the rising prevalence of obesity epidemic. An environmental obesogen is defined as a chemical that can alter lipid homeostasis to promote adipogenesis and lipid accumulation whereas an endocrine disrupting chemical (EDC) is defined as a synthetic chemical that can interfere with the endocrine function and cause adverse health effects. Many obesogens are EDCs that interfere with normal endocrine regulation of metabolism, adipose tissue development and maintenance, appetite, weight and energy balance. An expanding body of scientific evidence from animal and epidemiological studies has begun to provide links between exposure to EDCs and obesity. Despite the significance of environmental obesogens in the pathogenesis of metabolic diseases, the contribution of synthetic chemical exposure to obesity epidemic remains largely unrecognised. Hence, the purpose of this review is to provide a current update on the evidences from animal and human studies on the role of fourteen environmental obesogens in obesity, a comprehensive view of the mechanisms of action of these obesogens and current green and sustainable chemistry strategies to overcome chemical exposure to prevent obesity. Designing of safer version of obesogens through green chemistry approaches requires a collaborative undertaking to evaluate the toxicity of endocrine disruptors using appropriate experimental methods, which will help in developing a new generation of inherently safer chemicals. The Author(s). Published by Elsevier B.V. 2020-06 2020-06-30 /pmc/articles/PMC7326440/ http://dx.doi.org/10.1016/j.crgsc.2020.06.002 Text en © 2020 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Gupta, Radhika Kumar, Prashant Fahmi, Nighat Garg, Bhaskar Dutta, Sriparna Sachar, Shilpee Matharu, Avtar S. Vimaleswaran, Karani S. Endocrine disruption and obesity: A current review on environmental obesogens |
title | Endocrine disruption and obesity: A current review on environmental obesogens |
title_full | Endocrine disruption and obesity: A current review on environmental obesogens |
title_fullStr | Endocrine disruption and obesity: A current review on environmental obesogens |
title_full_unstemmed | Endocrine disruption and obesity: A current review on environmental obesogens |
title_short | Endocrine disruption and obesity: A current review on environmental obesogens |
title_sort | endocrine disruption and obesity: a current review on environmental obesogens |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326440/ http://dx.doi.org/10.1016/j.crgsc.2020.06.002 |
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