Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop

Activin A functions in BMP signaling in two ways: it either engages ACVR1B to activate Smad2/3 signaling or binds ACVR1 to form a non-signaling complex (NSC). Although the former property has been studied extensively, the roles of the NSC remain unexplored. The genetic disorder fibrodysplasia ossifi...

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Detalles Bibliográficos
Autores principales: Aykul, Senem, Corpina, Richard A, Goebel, Erich J, Cunanan, Camille J, Dimitriou, Alexandra, Kim, Hyon Jong, Zhang, Qian, Rafique, Ashique, Leidich, Raymond, Wang, Xin, McClain, Joyce, Jimenez, Johanna, Nannuru, Kalyan C, Rothman, Nyanza J, Lees-Shepard, John B, Martinez-Hackert, Erik, Murphy, Andrew J, Thompson, Thomas B, Economides, Aris N, Idone, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326492/
https://www.ncbi.nlm.nih.gov/pubmed/32515349
http://dx.doi.org/10.7554/eLife.54582

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