Cargando…

Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes

The lipid kinase VPS34 orchestrates diverse processes, including autophagy, endocytic sorting, phagocytosis, anabolic responses and cell division. VPS34 forms various complexes that help adapt it to specific pathways, with complexes I and II being the most prominent ones. We found that physicochemic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ohashi, Yohei, Tremel, Shirley, Masson, Glenn Robert, McGinney, Lauren, Boulanger, Jerome, Rostislavleva, Ksenia, Johnson, Christopher M, Niewczas, Izabella, Clark, Jonathan, Williams, Roger L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326497/ https://www.ncbi.nlm.nih.gov/pubmed/32602837 http://dx.doi.org/10.7554/eLife.58281

Ejemplares similares

VPS34 complexes from a structural perspective
por: Ohashi, Yohei, et al.
Publicado: (2019)

Design principles of the ESCRT-III Vps24-Vps2 module
por: Banjade, Sudeep, et al.
Publicado: (2021)

Activation Mechanisms of the VPS34 Complexes
por: Ohashi, Yohei
Publicado: (2021)

Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex
por: Ohashi, Yohei, et al.
Publicado: (2016)

Phosphoproteomic identification of ULK substrates reveals VPS15‐dependent ULK/VPS34 interplay in the regulation of autophagy
por: Mercer, Thomas John, et al.
Publicado: (2021)

Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases
por: Han, Han, et al.
Publicado: (2019)

A conserved and regulated mechanism drives endosomal Rab transition
por: Langemeyer, Lars, et al.
Publicado: (2020)

The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets
por: Han, Han, et al.
Publicado: (2017)

The autophagic membrane tether ATG2A transfers lipids between membranes
por: Maeda, Shintaro, et al.
Publicado: (2019)

Proteasome storage granules protect proteasomes from autophagic degradation upon carbon starvation
por: Marshall, Richard S, et al.
Publicado: (2018)

Retraction: Proteasome storage granules protect proteasomes from autophagic degradation upon carbon starvation
por: Vierstra, Richard David
Publicado: (2022)

Molecular mechanism to target the endosomal Mon1-Ccz1 GEF complex to the pre-autophagosomal structure
por: Gao, Jieqiong, et al.
Publicado: (2018)

Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes
por: Tremel, Shirley, et al.
Publicado: (2021)

Early Endosomal Vps34-Derived Phosphatidylinositol-3-Phosphate Is Indispensable for the Biogenesis of the Endosomal Recycling Compartment
por: Marcelić, Marina, et al.
Publicado: (2022)

Controlling protein function by fine-tuning conformational flexibility
por: Schmid, Sonja, et al.
Publicado: (2020)

Human VPS34 is required for internal vesicle formation within multivesicular endosomes
por: Futter, C.E., et al.
Publicado: (2001)

Tyrosine phosphorylation tunes chemical and thermal sensitivity of TRPV2 ion channel
por: Mo, Xiaoyi, et al.
Publicado: (2022)

Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase
por: Monroe, Nicole, et al.
Publicado: (2017)

Snf1/AMPK fine-tunes TORC1 signaling in response to glucose starvation
por: Caligaris, Marco, et al.
Publicado: (2023)

Dynamics of mTORC1 activation in response to amino acids
por: Manifava, Maria, et al.
Publicado: (2016)

Tuning site-specific dynamics to drive allosteric activation in a pneumococcal zinc uptake regulator
por: Capdevila, Daiana A, et al.
Publicado: (2018)

Critical Role for Phosphatidylinositol-3 Kinase Vps34/PIK3C3 in ON-Bipolar Cells
por: He, Feng, et al.
Publicado: (2019)

Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity
por: Nygren, Patrick J, et al.
Publicado: (2017)

Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells
por: Brian, Ben F, et al.
Publicado: (2019)

Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen
por: Shah, Neel H, et al.
Publicado: (2018)

A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes
por: Gschweitl, Michaela, et al.
Publicado: (2016)

A CDC25 family protein phosphatase gates cargo recognition by the Vps26 retromer subunit
por: Cui, Tie-Zhong, et al.
Publicado: (2017)

Phosphorylation of the N-terminus of Syntaxin-16 controls interaction with mVps45 and GLUT4 trafficking in adipocytes
por: Bremner, Shaun K., et al.
Publicado: (2023)

VPS35 leaves endosomes lost in transition
por: Leslie, Mitch
Publicado: (2011)

Beclin 1 Is Required for Neuron Viability and Regulates Endosome Pathways via the UVRAG-VPS34 Complex
por: McKnight, Nicole C., et al.
Publicado: (2014)

SM proteins Sly1 and Vps33 co-assemble with Sec17 and SNARE complexes to oppose SNARE disassembly by Sec18
por: Lobingier, Braden T, et al.
Publicado: (2014)

Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace
por: Heimhalt, Maren, et al.
Publicado: (2021)

Novel RNA and DNA strand exchange activity of the PALB2 DNA binding domain and its critical role for DNA repair in cells
por: Deveryshetty, Jaigeeth, et al.
Publicado: (2019)

Lipid kinases VPS34 and PIKfyve coordinate a phosphoinositide cascade to regulate retriever-mediated recycling on endosomes
por: Giridharan, Sai Srinivas Panapakkam, et al.
Publicado: (2022)

Control of cyclic oligoadenylate synthesis in a type III CRISPR system
por: Rouillon, Christophe, et al.
Publicado: (2018)

Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes
por: Wartosch, Lena, et al.
Publicado: (2015)

The dynamic interplay of host and viral enzymes in type III CRISPR-mediated cyclic nucleotide signalling
por: Athukoralage, Januka S, et al.
Publicado: (2020)

Ubiquitination of the PI3-kinase VPS-34 promotes VPS-34 stability and phagosome maturation
por: Liu, Jinchao, et al.
Publicado: (2018)

Tetramerisation of the CRISPR ring nuclease Crn3/Csx3 facilitates cyclic oligoadenylate cleavage
por: Athukoralage, Januka S, et al.
Publicado: (2020)

Endosome to Golgi Retrieval of the Vacuolar Protein Sorting Receptor, Vps10p, Requires the Function of the VPS29, VPS30, and VPS35 Gene Products
por: Seaman, Matthew N.J., et al.
Publicado: (1997)

Cannot write session to /tmp/vufind_sessions/sess_rs0p1km30fhdq0fhjg662bmca9