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Assessment of neonatal EEG background and neurodevelopment in full-term small for their gestational age infants

BACKGROUND: Delayed brain function development in small-gestational-age (SGA) infants has been reported. We aimed to quantify rates of immature neonatal EEG patterns and their association with neurodevelopment in SGA full-term neonates. METHODS: Using a cohort design, 50 SGA (birthweight <10th pe...

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Autores principales: Castro Conde, José R., González Campo, Candelaria, González González, Nieves L., Reyes Millán, Beatriz, González Barrios, Desiré, Jiménez Sosa, Alejandro, Quintero Fuentes, Itziar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326702/
https://www.ncbi.nlm.nih.gov/pubmed/31822017
http://dx.doi.org/10.1038/s41390-019-0693-0
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author Castro Conde, José R.
González Campo, Candelaria
González González, Nieves L.
Reyes Millán, Beatriz
González Barrios, Desiré
Jiménez Sosa, Alejandro
Quintero Fuentes, Itziar
author_facet Castro Conde, José R.
González Campo, Candelaria
González González, Nieves L.
Reyes Millán, Beatriz
González Barrios, Desiré
Jiménez Sosa, Alejandro
Quintero Fuentes, Itziar
author_sort Castro Conde, José R.
collection PubMed
description BACKGROUND: Delayed brain function development in small-gestational-age (SGA) infants has been reported. We aimed to quantify rates of immature neonatal EEG patterns and their association with neurodevelopment in SGA full-term neonates. METHODS: Using a cohort design, 50 SGA (birthweight <10th percentile) and 44 appropriate-gestational-age (AGA) term neonates underwent continuous video-EEG recordings lasting >3 h. Seventy-three of them were assessed at 2-years-old using Bayley-III-Scales. For EEG analysis, several segments of discontinuous/alternating EEG tracings were selected. Main outcomes measured: (1) Visual analysis (patterns of EEG maturity); (2) Power spectrum in δ, θ, α and β frequency bands; and (3) scores in motor, cognitive and language development. RESULTS: (1) SGA infants, compared to AGA, showed: (a) higher percentages of discontinuous EEG, both asynchrony and interhemispheric asymmetry, and bursts with delta-brushes, longer interburst-interval duration and more transients/hour; (b) lower relative power spectrum in δ and higher in α; and (c) lower scores on motor, language and cognitive neurodevelopment. (2) Asymmetry >5%, interburst-interval >5 s, discontinuity >11%, and bursts with delta-brushes >11% were associated with lower scores on Bayley-III. CONCLUSIONS: In this prospective study, SGA full-term neonates showed high rates of immature EEG patterns. Low-birthweight and immaturity EEG were both correlated with low development scores.
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spelling pubmed-73267022020-07-07 Assessment of neonatal EEG background and neurodevelopment in full-term small for their gestational age infants Castro Conde, José R. González Campo, Candelaria González González, Nieves L. Reyes Millán, Beatriz González Barrios, Desiré Jiménez Sosa, Alejandro Quintero Fuentes, Itziar Pediatr Res Clinical Research Article BACKGROUND: Delayed brain function development in small-gestational-age (SGA) infants has been reported. We aimed to quantify rates of immature neonatal EEG patterns and their association with neurodevelopment in SGA full-term neonates. METHODS: Using a cohort design, 50 SGA (birthweight <10th percentile) and 44 appropriate-gestational-age (AGA) term neonates underwent continuous video-EEG recordings lasting >3 h. Seventy-three of them were assessed at 2-years-old using Bayley-III-Scales. For EEG analysis, several segments of discontinuous/alternating EEG tracings were selected. Main outcomes measured: (1) Visual analysis (patterns of EEG maturity); (2) Power spectrum in δ, θ, α and β frequency bands; and (3) scores in motor, cognitive and language development. RESULTS: (1) SGA infants, compared to AGA, showed: (a) higher percentages of discontinuous EEG, both asynchrony and interhemispheric asymmetry, and bursts with delta-brushes, longer interburst-interval duration and more transients/hour; (b) lower relative power spectrum in δ and higher in α; and (c) lower scores on motor, language and cognitive neurodevelopment. (2) Asymmetry >5%, interburst-interval >5 s, discontinuity >11%, and bursts with delta-brushes >11% were associated with lower scores on Bayley-III. CONCLUSIONS: In this prospective study, SGA full-term neonates showed high rates of immature EEG patterns. Low-birthweight and immaturity EEG were both correlated with low development scores. Nature Publishing Group US 2019-12-10 2020 /pmc/articles/PMC7326702/ /pubmed/31822017 http://dx.doi.org/10.1038/s41390-019-0693-0 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, and provide a link to the Creative Commons license. You do not have permission under this license to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
spellingShingle Clinical Research Article
Castro Conde, José R.
González Campo, Candelaria
González González, Nieves L.
Reyes Millán, Beatriz
González Barrios, Desiré
Jiménez Sosa, Alejandro
Quintero Fuentes, Itziar
Assessment of neonatal EEG background and neurodevelopment in full-term small for their gestational age infants
title Assessment of neonatal EEG background and neurodevelopment in full-term small for their gestational age infants
title_full Assessment of neonatal EEG background and neurodevelopment in full-term small for their gestational age infants
title_fullStr Assessment of neonatal EEG background and neurodevelopment in full-term small for their gestational age infants
title_full_unstemmed Assessment of neonatal EEG background and neurodevelopment in full-term small for their gestational age infants
title_short Assessment of neonatal EEG background and neurodevelopment in full-term small for their gestational age infants
title_sort assessment of neonatal eeg background and neurodevelopment in full-term small for their gestational age infants
topic Clinical Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326702/
https://www.ncbi.nlm.nih.gov/pubmed/31822017
http://dx.doi.org/10.1038/s41390-019-0693-0
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