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[(18)F]FDG uptake of bone marrow on PET/CT for predicting distant recurrence in breast cancer patients after surgical resection
BACKGROUND: The objective of this study was to investigate the prognostic value of 2-Deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) uptake of bone marrow (BM) and metabolic parameters of primary tumor on positron emission tomography/computed tomography (PET/CT) for predicting distant recurrence in pat...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326752/ https://www.ncbi.nlm.nih.gov/pubmed/32607957 http://dx.doi.org/10.1186/s13550-020-00660-y |
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author | Lee, Jeong Won Kim, Sung Yong Han, Sun Wook Lee, Jong Eun Lee, Hyun Ju Heo, Nam Hun Lee, Sang Mi |
author_facet | Lee, Jeong Won Kim, Sung Yong Han, Sun Wook Lee, Jong Eun Lee, Hyun Ju Heo, Nam Hun Lee, Sang Mi |
author_sort | Lee, Jeong Won |
collection | PubMed |
description | BACKGROUND: The objective of this study was to investigate the prognostic value of 2-Deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) uptake of bone marrow (BM) and metabolic parameters of primary tumor on positron emission tomography/computed tomography (PET/CT) for predicting distant recurrence in patients with breast cancer. METHODS: Pretreatment [(18)F]FDG PET/CT images of 345 breast cancer patients were retrospectively evaluated. Maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis (TLG) of primary breast cancer and bone marrow-to-liver uptake ratio (BLR) on PET/CT were measured. A Cox proportional hazard regression model was used to evaluate the prognostic potential of parameters for predicting recurrence-free survival (RFS) and distant RFS. For Kaplan-Meier analysis, the specific cutoff values pf BLR and TLG were determined by the maximal chi-square method. RESULTS: The median follow-up duration of the enrolled patients was 48.7 months, and during follow-up, 36 patients (10.4%) experienced the cancer recurrence. BLR was significantly correlated with T stage, serum inflammatory markers, and recurrence pattern (p < 0.05). Patients with high BLR and TLG showed worse RFS and distant RFS than those with low BLR and TLG. On multivariate analysis, BLR was significantly associated with both RFS and distant RFS after adjusting for T stage, estrogen receptor status, and TLG (p = 0.001 for both). Only 0.5% of patients with TLG < 9.64 g and BLR < 0.91 experienced distant recurrence. However, patients with TLG ≥ 9.64 g and BLR ≥ 0.91 had a distant recurrence rate of 40.7%. CONCLUSIONS: BLR on pretreatment [(18)F]FDG PET/CT were significant predictors for RFS and distant RFS in patients with breast cancer. By combining [(18)F]FDG uptake of BM and volumetric PET/CT index of breast cancer, the risk of distant recurrence could be stratified. |
format | Online Article Text |
id | pubmed-7326752 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-73267522020-07-07 [(18)F]FDG uptake of bone marrow on PET/CT for predicting distant recurrence in breast cancer patients after surgical resection Lee, Jeong Won Kim, Sung Yong Han, Sun Wook Lee, Jong Eun Lee, Hyun Ju Heo, Nam Hun Lee, Sang Mi EJNMMI Res Original Research BACKGROUND: The objective of this study was to investigate the prognostic value of 2-Deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) uptake of bone marrow (BM) and metabolic parameters of primary tumor on positron emission tomography/computed tomography (PET/CT) for predicting distant recurrence in patients with breast cancer. METHODS: Pretreatment [(18)F]FDG PET/CT images of 345 breast cancer patients were retrospectively evaluated. Maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis (TLG) of primary breast cancer and bone marrow-to-liver uptake ratio (BLR) on PET/CT were measured. A Cox proportional hazard regression model was used to evaluate the prognostic potential of parameters for predicting recurrence-free survival (RFS) and distant RFS. For Kaplan-Meier analysis, the specific cutoff values pf BLR and TLG were determined by the maximal chi-square method. RESULTS: The median follow-up duration of the enrolled patients was 48.7 months, and during follow-up, 36 patients (10.4%) experienced the cancer recurrence. BLR was significantly correlated with T stage, serum inflammatory markers, and recurrence pattern (p < 0.05). Patients with high BLR and TLG showed worse RFS and distant RFS than those with low BLR and TLG. On multivariate analysis, BLR was significantly associated with both RFS and distant RFS after adjusting for T stage, estrogen receptor status, and TLG (p = 0.001 for both). Only 0.5% of patients with TLG < 9.64 g and BLR < 0.91 experienced distant recurrence. However, patients with TLG ≥ 9.64 g and BLR ≥ 0.91 had a distant recurrence rate of 40.7%. CONCLUSIONS: BLR on pretreatment [(18)F]FDG PET/CT were significant predictors for RFS and distant RFS in patients with breast cancer. By combining [(18)F]FDG uptake of BM and volumetric PET/CT index of breast cancer, the risk of distant recurrence could be stratified. Springer Berlin Heidelberg 2020-06-30 /pmc/articles/PMC7326752/ /pubmed/32607957 http://dx.doi.org/10.1186/s13550-020-00660-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Original Research Lee, Jeong Won Kim, Sung Yong Han, Sun Wook Lee, Jong Eun Lee, Hyun Ju Heo, Nam Hun Lee, Sang Mi [(18)F]FDG uptake of bone marrow on PET/CT for predicting distant recurrence in breast cancer patients after surgical resection |
title | [(18)F]FDG uptake of bone marrow on PET/CT for predicting distant recurrence in breast cancer patients after surgical resection |
title_full | [(18)F]FDG uptake of bone marrow on PET/CT for predicting distant recurrence in breast cancer patients after surgical resection |
title_fullStr | [(18)F]FDG uptake of bone marrow on PET/CT for predicting distant recurrence in breast cancer patients after surgical resection |
title_full_unstemmed | [(18)F]FDG uptake of bone marrow on PET/CT for predicting distant recurrence in breast cancer patients after surgical resection |
title_short | [(18)F]FDG uptake of bone marrow on PET/CT for predicting distant recurrence in breast cancer patients after surgical resection |
title_sort | [(18)f]fdg uptake of bone marrow on pet/ct for predicting distant recurrence in breast cancer patients after surgical resection |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326752/ https://www.ncbi.nlm.nih.gov/pubmed/32607957 http://dx.doi.org/10.1186/s13550-020-00660-y |
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