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Nitric Oxide-Producing Cardiovascular Stent Coatings for Prevention of Thrombosis and Restenosis

Cardiovascular stenting is an effective method for treating cardiovascular diseases (CVDs), yet thrombosis and restenosis are the two major clinical complications that often lead to device failure. Nitric oxide (NO) has been proposed as a promising small molecule in improving the clinical performanc...

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Autores principales: Rao, Jingdong, Pan Bei, Ho, Yang, Yuhe, Liu, Yu, Lin, Haodong, Zhao, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326943/
https://www.ncbi.nlm.nih.gov/pubmed/32671029
http://dx.doi.org/10.3389/fbioe.2020.00578
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author Rao, Jingdong
Pan Bei, Ho
Yang, Yuhe
Liu, Yu
Lin, Haodong
Zhao, Xin
author_facet Rao, Jingdong
Pan Bei, Ho
Yang, Yuhe
Liu, Yu
Lin, Haodong
Zhao, Xin
author_sort Rao, Jingdong
collection PubMed
description Cardiovascular stenting is an effective method for treating cardiovascular diseases (CVDs), yet thrombosis and restenosis are the two major clinical complications that often lead to device failure. Nitric oxide (NO) has been proposed as a promising small molecule in improving the clinical performance of cardiovascular stents thanks to its anti-thrombosis and anti-restenosis ability, but its short half-life limits the full use of NO. To produce NO at lesion site with sufficient amount, NO-producing coatings (including NO-releasing and NO-generating coatings) are fashioned. Its releasing strategy is achieved by introducing exogenous NO storage materials like NO donors, while the generating strategy utilizes the in vivo substances such as S-nitrosothiols (RSNOs) to generate NO flux. NO-producing stents are particularly promising in future clinical use due to their ability to store NO resources or to generate large NO flux in a controlled and efficient manner. In this review, we first introduce NO-releasing and -generating coatings for prevention of thrombosis and restenosis. We then discuss the advantages and drawbacks on releasing and generating aspects, where possible further developments are suggested.
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spelling pubmed-73269432020-07-14 Nitric Oxide-Producing Cardiovascular Stent Coatings for Prevention of Thrombosis and Restenosis Rao, Jingdong Pan Bei, Ho Yang, Yuhe Liu, Yu Lin, Haodong Zhao, Xin Front Bioeng Biotechnol Bioengineering and Biotechnology Cardiovascular stenting is an effective method for treating cardiovascular diseases (CVDs), yet thrombosis and restenosis are the two major clinical complications that often lead to device failure. Nitric oxide (NO) has been proposed as a promising small molecule in improving the clinical performance of cardiovascular stents thanks to its anti-thrombosis and anti-restenosis ability, but its short half-life limits the full use of NO. To produce NO at lesion site with sufficient amount, NO-producing coatings (including NO-releasing and NO-generating coatings) are fashioned. Its releasing strategy is achieved by introducing exogenous NO storage materials like NO donors, while the generating strategy utilizes the in vivo substances such as S-nitrosothiols (RSNOs) to generate NO flux. NO-producing stents are particularly promising in future clinical use due to their ability to store NO resources or to generate large NO flux in a controlled and efficient manner. In this review, we first introduce NO-releasing and -generating coatings for prevention of thrombosis and restenosis. We then discuss the advantages and drawbacks on releasing and generating aspects, where possible further developments are suggested. Frontiers Media S.A. 2020-06-24 /pmc/articles/PMC7326943/ /pubmed/32671029 http://dx.doi.org/10.3389/fbioe.2020.00578 Text en Copyright © 2020 Rao, Pan Bei, Yang, Liu, Lin and Zhao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Rao, Jingdong
Pan Bei, Ho
Yang, Yuhe
Liu, Yu
Lin, Haodong
Zhao, Xin
Nitric Oxide-Producing Cardiovascular Stent Coatings for Prevention of Thrombosis and Restenosis
title Nitric Oxide-Producing Cardiovascular Stent Coatings for Prevention of Thrombosis and Restenosis
title_full Nitric Oxide-Producing Cardiovascular Stent Coatings for Prevention of Thrombosis and Restenosis
title_fullStr Nitric Oxide-Producing Cardiovascular Stent Coatings for Prevention of Thrombosis and Restenosis
title_full_unstemmed Nitric Oxide-Producing Cardiovascular Stent Coatings for Prevention of Thrombosis and Restenosis
title_short Nitric Oxide-Producing Cardiovascular Stent Coatings for Prevention of Thrombosis and Restenosis
title_sort nitric oxide-producing cardiovascular stent coatings for prevention of thrombosis and restenosis
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326943/
https://www.ncbi.nlm.nih.gov/pubmed/32671029
http://dx.doi.org/10.3389/fbioe.2020.00578
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