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Centrosome dysfunction: a link between senescence and tumor immunity

Centrosome aberrations are hallmarks of human cancers and contribute to the senescence process. Structural and numerical centrosome abnormalities trigger mitotic errors, cellular senescence, cell death, genomic instability and/or aneuploidy, resulting in human disorders such as aging and cancer and...

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Autores principales: Wu, Qi, Li, Bei, Liu, Le, Sun, Shengrong, Sun, Si
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327052/
https://www.ncbi.nlm.nih.gov/pubmed/32606370
http://dx.doi.org/10.1038/s41392-020-00214-7
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author Wu, Qi
Li, Bei
Liu, Le
Sun, Shengrong
Sun, Si
author_facet Wu, Qi
Li, Bei
Liu, Le
Sun, Shengrong
Sun, Si
author_sort Wu, Qi
collection PubMed
description Centrosome aberrations are hallmarks of human cancers and contribute to the senescence process. Structural and numerical centrosome abnormalities trigger mitotic errors, cellular senescence, cell death, genomic instability and/or aneuploidy, resulting in human disorders such as aging and cancer and affecting immunity. Interestingly, centrosome dysfunction promotes the secretion of multiple inflammatory factors that act as pivotal drivers of senescence and tumor immune escape. In this review, we summarize the forms of centrosome dysfunction and further discuss recent advances indicating that centrosome defects contribute to acceleration of senescence progression and promotion of tumor cell immune evasion in different ways.
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spelling pubmed-73270522020-07-06 Centrosome dysfunction: a link between senescence and tumor immunity Wu, Qi Li, Bei Liu, Le Sun, Shengrong Sun, Si Signal Transduct Target Ther Review Article Centrosome aberrations are hallmarks of human cancers and contribute to the senescence process. Structural and numerical centrosome abnormalities trigger mitotic errors, cellular senescence, cell death, genomic instability and/or aneuploidy, resulting in human disorders such as aging and cancer and affecting immunity. Interestingly, centrosome dysfunction promotes the secretion of multiple inflammatory factors that act as pivotal drivers of senescence and tumor immune escape. In this review, we summarize the forms of centrosome dysfunction and further discuss recent advances indicating that centrosome defects contribute to acceleration of senescence progression and promotion of tumor cell immune evasion in different ways. Nature Publishing Group UK 2020-06-30 /pmc/articles/PMC7327052/ /pubmed/32606370 http://dx.doi.org/10.1038/s41392-020-00214-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Wu, Qi
Li, Bei
Liu, Le
Sun, Shengrong
Sun, Si
Centrosome dysfunction: a link between senescence and tumor immunity
title Centrosome dysfunction: a link between senescence and tumor immunity
title_full Centrosome dysfunction: a link between senescence and tumor immunity
title_fullStr Centrosome dysfunction: a link between senescence and tumor immunity
title_full_unstemmed Centrosome dysfunction: a link between senescence and tumor immunity
title_short Centrosome dysfunction: a link between senescence and tumor immunity
title_sort centrosome dysfunction: a link between senescence and tumor immunity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327052/
https://www.ncbi.nlm.nih.gov/pubmed/32606370
http://dx.doi.org/10.1038/s41392-020-00214-7
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