The interaction between ferroptosis and lipid metabolism in cancer

Ferroptosis is a new form of programmed cell death characterized by the accumulation of iron-dependent lethal lipid peroxides. Recent discoveries have focused on alterations that occur in lipid metabolism during ferroptosis and have provided intriguing insights into the interplay between ferroptosis...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Dingshan, Li, Yongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327075/
https://www.ncbi.nlm.nih.gov/pubmed/32606298
http://dx.doi.org/10.1038/s41392-020-00216-5
_version_ 1783552467064061952
author Li, Dingshan
Li, Yongsheng
author_facet Li, Dingshan
Li, Yongsheng
author_sort Li, Dingshan
collection PubMed
description Ferroptosis is a new form of programmed cell death characterized by the accumulation of iron-dependent lethal lipid peroxides. Recent discoveries have focused on alterations that occur in lipid metabolism during ferroptosis and have provided intriguing insights into the interplay between ferroptosis and lipid metabolism in cancer. Their interaction regulates the initiation, development, metastasis, therapy resistance of cancer, as well as the tumor immunity, which offers several potential strategies for cancer treatment. This review is a brief overview of the features characterizing the interaction between ferroptosis and lipid metabolism, and highlights the significance of this interaction in cancer.
format Online
Article
Text
id pubmed-7327075
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-73270752020-07-06 The interaction between ferroptosis and lipid metabolism in cancer Li, Dingshan Li, Yongsheng Signal Transduct Target Ther Review Article Ferroptosis is a new form of programmed cell death characterized by the accumulation of iron-dependent lethal lipid peroxides. Recent discoveries have focused on alterations that occur in lipid metabolism during ferroptosis and have provided intriguing insights into the interplay between ferroptosis and lipid metabolism in cancer. Their interaction regulates the initiation, development, metastasis, therapy resistance of cancer, as well as the tumor immunity, which offers several potential strategies for cancer treatment. This review is a brief overview of the features characterizing the interaction between ferroptosis and lipid metabolism, and highlights the significance of this interaction in cancer. Nature Publishing Group UK 2020-06-30 /pmc/articles/PMC7327075/ /pubmed/32606298 http://dx.doi.org/10.1038/s41392-020-00216-5 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Li, Dingshan
Li, Yongsheng
The interaction between ferroptosis and lipid metabolism in cancer
title The interaction between ferroptosis and lipid metabolism in cancer
title_full The interaction between ferroptosis and lipid metabolism in cancer
title_fullStr The interaction between ferroptosis and lipid metabolism in cancer
title_full_unstemmed The interaction between ferroptosis and lipid metabolism in cancer
title_short The interaction between ferroptosis and lipid metabolism in cancer
title_sort interaction between ferroptosis and lipid metabolism in cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327075/
https://www.ncbi.nlm.nih.gov/pubmed/32606298
http://dx.doi.org/10.1038/s41392-020-00216-5
work_keys_str_mv AT lidingshan theinteractionbetweenferroptosisandlipidmetabolismincancer
AT liyongsheng theinteractionbetweenferroptosisandlipidmetabolismincancer
AT lidingshan interactionbetweenferroptosisandlipidmetabolismincancer
AT liyongsheng interactionbetweenferroptosisandlipidmetabolismincancer

Ejemplares similares