Metformin Ameliorates Synaptic Defects in a Mouse Model of AD by Inhibiting Cdk5 Activity

Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is activated by the neuron-specific activators p35/p39 and plays important roles in neuronal development, synaptic plasticity, and cognitive behavior. However, the proteolytic cleavage of p35 to p25 leads to prolonged and aberrant Cd...

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Detalles Bibliográficos
Autores principales: Wang, YaLi, Zhao, JianHua, Guo, Fang-Li, Gao, XiaHuan, Xie, Xine, Liu, ShouQing, Yang, Xin, Yang, XinFeng, Zhang, LuYi, Ye, YuXiao, Fan, LiBing, Wang, JianGang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327108/
https://www.ncbi.nlm.nih.gov/pubmed/32670025
http://dx.doi.org/10.3389/fncel.2020.00170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327108/
https://www.ncbi.nlm.nih.gov/pubmed/32670025
http://dx.doi.org/10.3389/fncel.2020.00170

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