Cargando…
A Systematic Review of Imaging Studies in the Combined and Inattentive Subtypes of Attention Deficit Hyperactivity Disorder
Objective: Insights to underlying neural mechanisms in attention deficit hyperactivity disorder (ADHD) have emerged from neuroimaging research; however, the neural mechanisms that distinguish ADHD subtypes remain inconclusive. Method: We reviewed 19 studies integrating magnetic resonance imaging [MR...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327109/ https://www.ncbi.nlm.nih.gov/pubmed/32670028 http://dx.doi.org/10.3389/fnint.2020.00031 |
_version_ | 1783552475063648256 |
---|---|
author | Saad, Jacqueline Fifi Griffiths, Kristi R. Korgaonkar, Mayuresh S. |
author_facet | Saad, Jacqueline Fifi Griffiths, Kristi R. Korgaonkar, Mayuresh S. |
author_sort | Saad, Jacqueline Fifi |
collection | PubMed |
description | Objective: Insights to underlying neural mechanisms in attention deficit hyperactivity disorder (ADHD) have emerged from neuroimaging research; however, the neural mechanisms that distinguish ADHD subtypes remain inconclusive. Method: We reviewed 19 studies integrating magnetic resonance imaging [MRI; structural (sMRI), diffusion, functional MRI (fMRI)] findings into a framework exploring pathophysiological mechanisms underlying the combined (ADHD-C) and predominantly inattentive (ADHD-I) ADHD subtypes. Results: Despite equivocal structural MRI results, findings from fMRI and DTI imaging modalities consistently implicate disrupted connectivity in regions and tracts involving frontal striatal thalamic in ADHD-C and frontoparietal neural networks in ADHD-I. Alterations of the default mode, cerebellum, and motor networks in ADHD-C and cingulo-frontoparietal attention and visual networks in ADHD-I highlight network organization differences between subtypes. Conclusion: Growing evidence from neuroimaging studies highlight neurobiological differences between ADHD clinical subtypes, particularly from a network perspective. Understanding brain network organization and connectivity may help us to better conceptualize the ADHD types and their symptom variability. |
format | Online Article Text |
id | pubmed-7327109 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73271092020-07-14 A Systematic Review of Imaging Studies in the Combined and Inattentive Subtypes of Attention Deficit Hyperactivity Disorder Saad, Jacqueline Fifi Griffiths, Kristi R. Korgaonkar, Mayuresh S. Front Integr Neurosci Neuroscience Objective: Insights to underlying neural mechanisms in attention deficit hyperactivity disorder (ADHD) have emerged from neuroimaging research; however, the neural mechanisms that distinguish ADHD subtypes remain inconclusive. Method: We reviewed 19 studies integrating magnetic resonance imaging [MRI; structural (sMRI), diffusion, functional MRI (fMRI)] findings into a framework exploring pathophysiological mechanisms underlying the combined (ADHD-C) and predominantly inattentive (ADHD-I) ADHD subtypes. Results: Despite equivocal structural MRI results, findings from fMRI and DTI imaging modalities consistently implicate disrupted connectivity in regions and tracts involving frontal striatal thalamic in ADHD-C and frontoparietal neural networks in ADHD-I. Alterations of the default mode, cerebellum, and motor networks in ADHD-C and cingulo-frontoparietal attention and visual networks in ADHD-I highlight network organization differences between subtypes. Conclusion: Growing evidence from neuroimaging studies highlight neurobiological differences between ADHD clinical subtypes, particularly from a network perspective. Understanding brain network organization and connectivity may help us to better conceptualize the ADHD types and their symptom variability. Frontiers Media S.A. 2020-06-24 /pmc/articles/PMC7327109/ /pubmed/32670028 http://dx.doi.org/10.3389/fnint.2020.00031 Text en Copyright © 2020 Saad, Griffiths and Korgaonkar. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Saad, Jacqueline Fifi Griffiths, Kristi R. Korgaonkar, Mayuresh S. A Systematic Review of Imaging Studies in the Combined and Inattentive Subtypes of Attention Deficit Hyperactivity Disorder |
title | A Systematic Review of Imaging Studies in the Combined and Inattentive Subtypes of Attention Deficit Hyperactivity Disorder |
title_full | A Systematic Review of Imaging Studies in the Combined and Inattentive Subtypes of Attention Deficit Hyperactivity Disorder |
title_fullStr | A Systematic Review of Imaging Studies in the Combined and Inattentive Subtypes of Attention Deficit Hyperactivity Disorder |
title_full_unstemmed | A Systematic Review of Imaging Studies in the Combined and Inattentive Subtypes of Attention Deficit Hyperactivity Disorder |
title_short | A Systematic Review of Imaging Studies in the Combined and Inattentive Subtypes of Attention Deficit Hyperactivity Disorder |
title_sort | systematic review of imaging studies in the combined and inattentive subtypes of attention deficit hyperactivity disorder |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327109/ https://www.ncbi.nlm.nih.gov/pubmed/32670028 http://dx.doi.org/10.3389/fnint.2020.00031 |
work_keys_str_mv | AT saadjacquelinefifi asystematicreviewofimagingstudiesinthecombinedandinattentivesubtypesofattentiondeficithyperactivitydisorder AT griffithskristir asystematicreviewofimagingstudiesinthecombinedandinattentivesubtypesofattentiondeficithyperactivitydisorder AT korgaonkarmayureshs asystematicreviewofimagingstudiesinthecombinedandinattentivesubtypesofattentiondeficithyperactivitydisorder AT saadjacquelinefifi systematicreviewofimagingstudiesinthecombinedandinattentivesubtypesofattentiondeficithyperactivitydisorder AT griffithskristir systematicreviewofimagingstudiesinthecombinedandinattentivesubtypesofattentiondeficithyperactivitydisorder AT korgaonkarmayureshs systematicreviewofimagingstudiesinthecombinedandinattentivesubtypesofattentiondeficithyperactivitydisorder |