Cargando…

Poncirin Inhibits Osteoclast Differentiation and Bone Loss through Down-Regulation of NFATc1 In Vitro and In Vivo

Activation of osteoclast and inactivation of osteoblast result in loss of bone mass with bone resorption, leading to the pathological progression of osteoporosis. The receptor activator of NF-κB ligand (RANKL) is a member of the TNF superfamily, and is a key mediator of osteoclast differentiation. A...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chun, Kwang-Hoon, Jin, Hyun Chul, Kang, Ki Sung, Chang, Tong-Shin, Hwang, Gwi Seo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Society of Applied Pharmacology 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327144/ https://www.ncbi.nlm.nih.gov/pubmed/31500404 http://dx.doi.org/10.4062/biomolther.2018.216

Ejemplares similares

Betulin Suppresses Osteoclast Formation via Down-Regulating NFATc1
por: Kim, Kwang-Jin, et al.
Publicado: (2018)

Suppression Effect of Astaxanthin on Osteoclast Formation In Vitro and Bone Loss In Vivo
por: Hwang, Yun-Ho, et al.
Publicado: (2018)

Regulation of NFATc1 in Osteoclast Differentiation
por: Kim, Jung Ha, et al.
Publicado: (2014)

Nitidine chloride prevents OVX-induced bone loss via suppressing NFATc1-mediated osteoclast differentiation
por: Liu, Qian, et al.
Publicado: (2016)

Protective effect of Korean Red Ginseng against glucocorticoid-induced osteoporosis in vitro and in vivo
por: Kim, Jinhee, et al.
Publicado: (2014)

Inhibitory Effect of Purpurogallin on Osteoclast Differentiation In Vitro through the Downregulation of c-Fos and NFATc1
por: Kim, Kiryeong, et al.
Publicado: (2018)

Zinc inhibits osteoclast differentiation by suppression of Ca(2+)-Calcineurin-NFATc1 signaling pathway
por: Park, Kwang Hwan, et al.
Publicado: (2013)

Parthenolide inhibits osteoclast differentiation and bone resorbing activity by down-regulation of NFATc1 induction and c-Fos stability, during RANKL-mediated osteoclastogenesis
por: Kim, Ju-Young, et al.
Publicado: (2014)

Inhibition of RANKL-stimulated osteoclast differentiation by Schisandra chinensis through down-regulation of NFATc1 and c-fos expression
por: Kim, Eun-Jung, et al.
Publicado: (2018)

Ethanol Extract of Atractylodes macrocephala Protects Bone Loss by Inhibiting Osteoclast Differentiation
por: Ha, Hyunil, et al.
Publicado: (2013)

Knockdown of Tcirg1 inhibits large-osteoclast generation by down-regulating NFATc1 and IP3R2 expression
por: Zhang, Dongyan, et al.
Publicado: (2020)

Oat Seedlings Extract Inhibits RANKL-Induced c-Fos/NFATc1 Transcription Factors in the Early Stage of Osteoclast Differentiation
por: Yang, Ji Yeong, et al.
Publicado: (2022)

Hypericin targets osteoclast and prevents breast cancer-induced bone metastasis via NFATc1 signaling pathway
por: Ouyang, Zhengxiao, et al.
Publicado: (2017)

Synovial Fluid Interleukin-16 Contributes to Osteoclast Activation and Bone Loss through the JNK/NFATc1 Signaling Cascade in Patients with Periprosthetic Joint Infection
por: Chang, Yuhan, et al.
Publicado: (2020)

mTORC1 impedes osteoclast differentiation via calcineurin and NFATc1
por: Huynh, HoangDinh, et al.
Publicado: (2018)

ThPOK Inhibits Osteoclast Formation Via NFATc1 Transcription and Function
por: Zou, Wei, et al.
Publicado: (2022)

Essentiality of Nfatc1 short isoform in osteoclast differentiation and its self-regulation
por: Omata, Yasuhiro, et al.
Publicado: (2023)

RCANs regulate the convergent roles of NFATc1 in bone homeostasis
por: Kim, Jung Ha, et al.
Publicado: (2016)

Flavonoid Glycosides from Ulmus macrocarpa Inhibit Osteoclast Differentiation via the Downregulation of NFATc1
por: Wang, Weihong, et al.
Publicado: (2022)

Umbelliferone Prevents Lipopolysaccharide-Induced Bone Loss and Suppresses RANKL-Induced Osteoclastogenesis by Attenuating Akt-c-Fos-NFATc1 Signaling
por: Kwak, Sung Chul, et al.
Publicado: (2019)

Correction: Hypericin targets osteoclast and prevents breast cancer-induced bone metastasis via NFATc1 signaling pathway
por: Ouyang, Zhengxiao, et al.
Publicado: (2019)

Anti-hyperalgesic properties of a flavanone derivative Poncirin in acute and chronic inflammatory pain models in mice
por: Afridi, Ruqayya, et al.
Publicado: (2019)

Effects of Poncirin, a Citrus Flavonoid and Its Aglycone, Isosakuranetin, on the Gut Microbial Diversity and Metabolomics in Mice
por: Cao, Xuedan, et al.
Publicado: (2022)

Monotropein Protects against Inflammatory Bone Loss and Suppresses Osteoclast Formation and Bone Resorption by Inhibiting NFATc1 via NF-κB and Akt/GSK-3β Pathway
por: Zhang, Qi, et al.
Publicado: (2022)

Chaenomelis fructus inhibits osteoclast differentiation by suppressing NFATc1 expression and prevents ovariectomy-induced osteoporosis
por: Kim, Minsun, et al.
Publicado: (2020)

Poncirin attenuates CCL4-induced liver injury through inhibition of oxidative stress and inflammatory cytokines in mice
por: Ullah, Hadayat, et al.
Publicado: (2020)

Poncirin suppresses lipopolysaccharide (LPS)-induced microglial inflammation and ameliorates brain ischemic injury in experimental stroke in mice
por: Yang, Li-Xuan, et al.
Publicado: (2020)

Sophorae Flos extract inhibits RANKL-induced osteoclast differentiation by suppressing the NF-κB/NFATc1 pathway in mouse bone marrow cells
por: Kim, Jeong-Mi, et al.
Publicado: (2017)

Osteostatin Inhibits M-CSF+RANKL-Induced Human Osteoclast Differentiation by Modulating NFATc1
por: Ibáñez, Lidia, et al.
Publicado: (2022)

Water extract of the fruits of Alpinia oxyphylla inhibits osteoclast differentiation and bone loss
por: Ha, Hyunil, et al.
Publicado: (2014)

Grape Seed Proanthocyanidin Extract Prevents Bone Loss via Regulation of Osteoclast Differentiation, Apoptosis, and Proliferation
por: Kwak, Sung Chul, et al.
Publicado: (2020)

Erratum to: Sophorae Flos extract inhibits RANKL-induced osteoclast differentiation by suppressing the NF-κB/NFATc1 pathway in mouse bone marrow cells
por: Kim, Jeong-Mi, et al.
Publicado: (2017)

Pristimerin Inhibits Osteoclast Differentiation and Bone Resorption in vitro and Prevents Ovariectomy-Induced Bone Loss in vivo
por: Sun, Peng, et al.
Publicado: (2020)

Retraction Note: Anti-hyperalgesic properties of a flavanone derivative Poncirin in acute and chronic inflammatory pain models in mice
por: Afridi, Ruqayya, et al.
Publicado: (2023)

In Vitro and In Vivo Effects of Gracilaria verrucosa Extracts on Osteoclast Differentiation
por: Kim, Kwang-Jin, et al.
Publicado: (2017)

NADPH oxidase gp91(phox) contributes to RANKL-induced osteoclast differentiation by upregulating NFATc1
por: Kang, In Soon, et al.
Publicado: (2016)

Tusc2/Fus1 regulates osteoclast differentiation through NF-κB and NFATc1
por: Kim, Inyoung, et al.
Publicado: (2017)

Inhibitory Effects of Rhaponticin on Osteoclast Formation and Resorption by Targeting RANKL-Induced NFATc1 and ROS Activity
por: He, Jianbo, et al.
Publicado: (2021)

Tectorigenin Promotes Osteoblast Differentiation and in vivo Bone Healing, but Suppresses Osteoclast Differentiation and in vivo Bone Resorption
por: Lee, So-Youn, et al.
Publicado: (2018)

Water Extract of Angelica dahurica Inhibits Osteoclast Differentiation and Bone Loss
por: Gu, Dong Ryun, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_uamgbuqs5q83m8tkh9apnb8sjh