1,2,3-Triazole β-lactam conjugates as antimicrobial agents

A convenient and efficient synthesis of new triazole β-lactam conjugates using click chemistry is described. β-lactam 15 and 16 were prepared using cycloaddition strategy and propargylated at N-1 to afford compounds 17 and 18. Cu-catalyzed click reaction of these β-lactams 17 and 18 with different a...

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Detalles Bibliográficos
Autores principales: Kaur, Rajneesh, Singh, Raman, Kumar, Antresh, Kaur, Satvinder, Priyadarshi, Nitesh, Singhal, Nitin Kumar, Singh, Kuldeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327255/
https://www.ncbi.nlm.nih.gov/pubmed/32637684
http://dx.doi.org/10.1016/j.heliyon.2020.e04241
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author Kaur, Rajneesh
Singh, Raman
Kumar, Antresh
Kaur, Satvinder
Priyadarshi, Nitesh
Singhal, Nitin Kumar
Singh, Kuldeep
author_facet Kaur, Rajneesh
Singh, Raman
Kumar, Antresh
Kaur, Satvinder
Priyadarshi, Nitesh
Singhal, Nitin Kumar
Singh, Kuldeep
author_sort Kaur, Rajneesh
collection PubMed
description A convenient and efficient synthesis of new triazole β-lactam conjugates using click chemistry is described. β-lactam 15 and 16 were prepared using cycloaddition strategy and propargylated at N-1 to afford compounds 17 and 18. Cu-catalyzed click reaction of these β-lactams 17 and 18 with different aryl azides provided 1,2,3-triazole conjugates 6 and 7, respectively. The products were fully characterized spectroscopically and tested against Gram-(+) and Gram-(-) bacteria. Compound 7a and 7c were found to be most active.
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spelling pubmed-73272552020-07-06 1,2,3-Triazole β-lactam conjugates as antimicrobial agents Kaur, Rajneesh Singh, Raman Kumar, Antresh Kaur, Satvinder Priyadarshi, Nitesh Singhal, Nitin Kumar Singh, Kuldeep Heliyon Article A convenient and efficient synthesis of new triazole β-lactam conjugates using click chemistry is described. β-lactam 15 and 16 were prepared using cycloaddition strategy and propargylated at N-1 to afford compounds 17 and 18. Cu-catalyzed click reaction of these β-lactams 17 and 18 with different aryl azides provided 1,2,3-triazole conjugates 6 and 7, respectively. The products were fully characterized spectroscopically and tested against Gram-(+) and Gram-(-) bacteria. Compound 7a and 7c were found to be most active. Elsevier 2020-06-27 /pmc/articles/PMC7327255/ /pubmed/32637684 http://dx.doi.org/10.1016/j.heliyon.2020.e04241 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Kaur, Rajneesh
Singh, Raman
Kumar, Antresh
Kaur, Satvinder
Priyadarshi, Nitesh
Singhal, Nitin Kumar
Singh, Kuldeep
1,2,3-Triazole β-lactam conjugates as antimicrobial agents
title 1,2,3-Triazole β-lactam conjugates as antimicrobial agents
title_full 1,2,3-Triazole β-lactam conjugates as antimicrobial agents
title_fullStr 1,2,3-Triazole β-lactam conjugates as antimicrobial agents
title_full_unstemmed 1,2,3-Triazole β-lactam conjugates as antimicrobial agents
title_short 1,2,3-Triazole β-lactam conjugates as antimicrobial agents
title_sort 1,2,3-triazole β-lactam conjugates as antimicrobial agents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327255/
https://www.ncbi.nlm.nih.gov/pubmed/32637684
http://dx.doi.org/10.1016/j.heliyon.2020.e04241
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