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Differentiate cavernous hemangioma from schwannoma with artificial intelligence (AI)
BACKGROUND: Cavernous hemangioma and schwannoma are tumors that both occur in the orbit. Because the treatment strategies of these two tumors are different, it is necessary to distinguish them at treatment initiation. Magnetic resonance imaging (MRI) is typically used to differentiate these two tumo...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327353/ https://www.ncbi.nlm.nih.gov/pubmed/32617330 http://dx.doi.org/10.21037/atm.2020.03.150 |
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author | Bi, Shaowei Chen, Rongxin Zhang, Kai Xiang, Yifan Wang, Ruixin Lin, Haotian Yang, Huasheng |
author_facet | Bi, Shaowei Chen, Rongxin Zhang, Kai Xiang, Yifan Wang, Ruixin Lin, Haotian Yang, Huasheng |
author_sort | Bi, Shaowei |
collection | PubMed |
description | BACKGROUND: Cavernous hemangioma and schwannoma are tumors that both occur in the orbit. Because the treatment strategies of these two tumors are different, it is necessary to distinguish them at treatment initiation. Magnetic resonance imaging (MRI) is typically used to differentiate these two tumor types; however, they present similar features in MRI images which increases the difficulty of differential diagnosis. This study aims to devise and develop an artificial intelligence framework to improve the accuracy of clinicians’ diagnoses and enable more effective treatment decisions by automatically distinguishing cavernous hemangioma from schwannoma. METHODS: Material: As the study materials, we chose MRI images as the study materials that represented patients from diverse areas in China who had been referred to our center from more than 45 different hospitals. All images were initially acquired on films, which we scanned into digital versions and recut. Finally, 11,489 images of cavernous hemangioma (from 33 different hospitals) and 3,478 images of schwannoma (from 16 different hospitals) were collected. Labeling: All images were labeled using standard anatomical knowledge and pathological diagnosis. Training: Three types of models were trained in sequence (a total of 96 models), with each model including a specific improvement. The first two model groups were eye- and tumor-positioning models designed to reduce the identification scope, while the third model group consisted of classification models trained to make the final diagnosis. RESULTS: First, internal four-fold cross-validation processes were conducted for all the models. During the validation of the first group, the 32 eye-positioning models were able to localize the position of the eyes with an average precision of 100%. In the second group, the 28 tumor-positioning models were able to reach an average precision above 90%. Subsequently, using the third group, the accuracy of all 32 tumor classification models reached nearly 90%. Next, external validation processes of 32 tumor classification models were conducted. The results showed that the accuracy of the transverse T1-weighted contrast-enhanced sequence reached 91.13%; the accuracy of the remaining models was significantly lower compared with the ground truth. CONCLUSIONS: The findings of this retrospective study show that an artificial intelligence framework can achieve high accuracy, sensitivity, and specificity in automated differential diagnosis between cavernous hemangioma and schwannoma in a real-world setting, which can help doctors determine appropriate treatments. |
format | Online Article Text |
id | pubmed-7327353 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-73273532020-07-01 Differentiate cavernous hemangioma from schwannoma with artificial intelligence (AI) Bi, Shaowei Chen, Rongxin Zhang, Kai Xiang, Yifan Wang, Ruixin Lin, Haotian Yang, Huasheng Ann Transl Med Original Article on Medical Artificial Intelligent Research BACKGROUND: Cavernous hemangioma and schwannoma are tumors that both occur in the orbit. Because the treatment strategies of these two tumors are different, it is necessary to distinguish them at treatment initiation. Magnetic resonance imaging (MRI) is typically used to differentiate these two tumor types; however, they present similar features in MRI images which increases the difficulty of differential diagnosis. This study aims to devise and develop an artificial intelligence framework to improve the accuracy of clinicians’ diagnoses and enable more effective treatment decisions by automatically distinguishing cavernous hemangioma from schwannoma. METHODS: Material: As the study materials, we chose MRI images as the study materials that represented patients from diverse areas in China who had been referred to our center from more than 45 different hospitals. All images were initially acquired on films, which we scanned into digital versions and recut. Finally, 11,489 images of cavernous hemangioma (from 33 different hospitals) and 3,478 images of schwannoma (from 16 different hospitals) were collected. Labeling: All images were labeled using standard anatomical knowledge and pathological diagnosis. Training: Three types of models were trained in sequence (a total of 96 models), with each model including a specific improvement. The first two model groups were eye- and tumor-positioning models designed to reduce the identification scope, while the third model group consisted of classification models trained to make the final diagnosis. RESULTS: First, internal four-fold cross-validation processes were conducted for all the models. During the validation of the first group, the 32 eye-positioning models were able to localize the position of the eyes with an average precision of 100%. In the second group, the 28 tumor-positioning models were able to reach an average precision above 90%. Subsequently, using the third group, the accuracy of all 32 tumor classification models reached nearly 90%. Next, external validation processes of 32 tumor classification models were conducted. The results showed that the accuracy of the transverse T1-weighted contrast-enhanced sequence reached 91.13%; the accuracy of the remaining models was significantly lower compared with the ground truth. CONCLUSIONS: The findings of this retrospective study show that an artificial intelligence framework can achieve high accuracy, sensitivity, and specificity in automated differential diagnosis between cavernous hemangioma and schwannoma in a real-world setting, which can help doctors determine appropriate treatments. AME Publishing Company 2020-06 /pmc/articles/PMC7327353/ /pubmed/32617330 http://dx.doi.org/10.21037/atm.2020.03.150 Text en 2020 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Original Article on Medical Artificial Intelligent Research Bi, Shaowei Chen, Rongxin Zhang, Kai Xiang, Yifan Wang, Ruixin Lin, Haotian Yang, Huasheng Differentiate cavernous hemangioma from schwannoma with artificial intelligence (AI) |
title | Differentiate cavernous hemangioma from schwannoma with artificial intelligence (AI) |
title_full | Differentiate cavernous hemangioma from schwannoma with artificial intelligence (AI) |
title_fullStr | Differentiate cavernous hemangioma from schwannoma with artificial intelligence (AI) |
title_full_unstemmed | Differentiate cavernous hemangioma from schwannoma with artificial intelligence (AI) |
title_short | Differentiate cavernous hemangioma from schwannoma with artificial intelligence (AI) |
title_sort | differentiate cavernous hemangioma from schwannoma with artificial intelligence (ai) |
topic | Original Article on Medical Artificial Intelligent Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327353/ https://www.ncbi.nlm.nih.gov/pubmed/32617330 http://dx.doi.org/10.21037/atm.2020.03.150 |
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