Altered brain language network in idiopathic peripheral facial paralysis patients with dysarthria

BACKGROUND: Dysarthria is one of the common symptoms of facial paralysis (FP). This study aimed to investigate functional alterations in the brain language network in early idiopathic peripheral FP patients with dysarthria using resting-state functional magnetic resonance imaging (fMRI). METHODS: A total of 45 cases of FP (left 22, right 23) and 34 cases of healthy control (HC) were recruited into this study. The data of patients with left-side FP and matched controls (17 cases) were flipped from left to right, and the brain regions were defined as ipsilateral and contralateral regions. The FC of 16 ROIs in classical language centers and regions that may be involved in language function were calculated. After identifying the differences of FC between the two groups, the correlation analysis between altered FC and TFGS score of oral muscle movement in FP group were analyzed. RESULTS: The FC between bilateral language regions has a significantly decreased trend in FP group compared with HC group (P<0.05). The ipsilateral inferior frontal gyrus, superior temporal gyrus, and middle temporal gyrus exhibited significantly decreased FC with multiple brain regions. In addition, we found that thalamus and cerebellum also with a significant alteration in FC in FP patients indicating that these two regions may also be involved in the mechanism of dysarthria in FP. The correlation analysis results indicated that the decrease of FC was positively correlated with the severity of oral paralysis. CONCLUSIONS: Idiopathic peripheral FP with dysarthria induces several FC alterations in the brain language network. The severity of oral paralysis is associated with these functional alterations.