Cargando…

C-Jun N-terminal kinase inhibitors: Structural insight into kinase-inhibitor complexes

The activation of c-Jun N-terminal kinases (JNKs) plays an important role in physiological processes including neuronal function, immune activity, and development, and thus, JNKs have been a therapeutic target for various diseases such as neurodegenerative diseases, inflammation, and cancer. Efforts...

Descripción completa

Detalles Bibliográficos
Autores principales:	Duong, Men Thi Hoai, Lee, Joon-Hwa, Ahn, Hee-Chul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Research Network of Computational and Structural Biotechnology 2020
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327381/ https://www.ncbi.nlm.nih.gov/pubmed/32637042 http://dx.doi.org/10.1016/j.csbj.2020.06.013

Ejemplares similares

Inhibitors of c-Jun N-terminal kinases—JuNK no more?
por: Bogoyevitch, Marie A., et al.
Publicado: (2008)

c-Jun N-Terminal Kinase Signaling Inhibitors Under Development
por: Han, Sun-Young
Publicado: (2008)

c-Jun N-Terminal Kinase Inhibitors as Potential Leads for New Therapeutics for Alzheimer’s Diseases
por: Hepp Rehfeldt, Stephanie Cristine, et al.
Publicado: (2020)

Novel Tryptanthrin Derivatives with Selectivity as c–Jun N–Terminal Kinase (JNK) 3 Inhibitors
por: Schepetkin, Igor A., et al.
Publicado: (2023)

c-Jun N-terminal kinase 2 suppresses pancreatic cancer growth and invasion and is opposed by c-Jun N-terminal kinase 1
por: Tian, Xiaodong, et al.
Publicado: (2021)

In vitro and in vivo neuroprotective effects of cJun N-terminal kinase inhibitors on retinal ganglion cells
por: Kim, Byung-Jin, et al.
Publicado: (2016)

Myocardial protective effects of a c‐Jun N‐terminal kinase inhibitor in rats with brain death
por: Guo, Wenzhi, et al.
Publicado: (2016)

Fragment-Based and Structural Investigation for Discovery of JNK3 Inhibitors
por: Duong, Men Thi Hoai, et al.
Publicado: (2022)

c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases
por: Guma, Monica, et al.
Publicado: (2012)

Investigating the role of c-Jun N-terminal kinases in the proliferation of Werner syndrome fibroblasts using diaminopyridine inhibitors
por: Davis, Terence, et al.
Publicado: (2011)

C‐Jun N‐terminal kinase signalling pathway in response to cisplatin
por: Yan, Dong, et al.
Publicado: (2016)

Evidence of Presynaptic Localization and Function of the c-Jun N-Terminal Kinase
por: Biggi, Silvia, et al.
Publicado: (2017)

Alarmins and c-Jun N-Terminal Kinase (JNK) Signaling in Neuroinflammation
por: Anfinogenova, Nina D., et al.
Publicado: (2020)

The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases
por: Chen, Jing, et al.
Publicado: (2021)

Protective Effects of a New C-Jun N-terminal Kinase Inhibitor in the Model of Global Cerebral Ischemia in Rats
por: Plotnikov, Mark B., et al.
Publicado: (2019)

Suppression of Age-Related Macular Degeneration-like Pathology by c-Jun N-Terminal Kinase Inhibitor IQ-1S
por: Zhdankina, Anna A., et al.
Publicado: (2023)

Cardioprotective Effects of a Selective c-Jun N-terminal Kinase Inhibitor in a Rat Model of Myocardial Infarction
por: Plotnikov, Mark B., et al.
Publicado: (2023)

Stressor-Like Effects of c-Jun N-Terminal Kinase (JNK) Inhibition
por: Clarke, Melanie, et al.
Publicado: (2012)

c-Jun N-Terminal Kinase Phosphorylation Is a Biomarker of Plitidepsin Activity
por: Muñoz-Alonso, María J., et al.
Publicado: (2013)

C-Jun N-terminal kinases are required for oncolytic adenovirus-mediated autophagy
por: Klein, SR, et al.
Publicado: (2015)

Activation of c-Jun N-terminal kinase by Akabane virus is required for apoptosis
por: Mitomo, S., et al.
Publicado: (2016)

A c-Jun N-terminal kinase inhibitor, JNK-IN-8, sensitizes triple negative breast cancer cells to lapatinib
por: Ebelt, Nancy D., et al.
Publicado: (2017)

Neuroprotective Effects of a Novel Inhibitor of c-Jun N-Terminal Kinase in the Rat Model of Transient Focal Cerebral Ischemia
por: Plotnikov, Mark B., et al.
Publicado: (2020)

Design, synthesis and biological evaluation of novel O-substituted tryptanthrin oxime derivatives as c-Jun N-terminal kinase inhibitors
por: Schepetkin, Igor A., et al.
Publicado: (2022)

Jun N-terminal kinase signaling makes a face
por: Hursh, Deborah A., et al.
Publicado: (2016)

Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-Terminal kinase pathway
por: Lee, Sang-il, et al.
Publicado: (2012)

Combination therapy of BCR-ABL-positive B cell acute lymphoblastic leukemia by tyrosine kinase inhibitor dasatinib and c-JUN N-terminal kinase inhibition
por: Xiao, Xinhua, et al.
Publicado: (2020)

Brain Targeting of 1,9-Pyrazoloanthrone an c-Jun-N-terminal Kinase Inhibitor Using Liposomes for Effective Management of Parkinson’s Disease
por: Ambhore, Nilesh Sudhakar, et al.
Publicado: (2017)

JNK‐IN‐8, a c‐Jun N‐terminal kinase inhibitor, improves functional recovery through suppressing neuroinflammation in ischemic stroke
por: Zheng, Jianjian, et al.
Publicado: (2019)

A Perspective on the Development of c-Jun N-terminal Kinase Inhibitors as Therapeutics for Alzheimer’s Disease: Investigating Structure through Docking Studies
por: Cho, Hyunwook, et al.
Publicado: (2021)

Tolerance to the antinociceptive effects of chronic morphine requires c-Jun N-terminal kinase
por: Marcus, David J., et al.
Publicado: (2015)

c-Jun N-Terminal Kinases (JNKs) in Myocardial and Cerebral Ischemia/Reperfusion Injury
por: Shvedova, Maria, et al.
Publicado: (2018)

c-Jun N-Terminal Kinase as a Therapeutic Target in Experimental Autoimmune Encephalomyelitis
por: Bagnoud, Maud, et al.
Publicado: (2020)

Molecular docking of C-Jun-N-Terminal Kinase (Jnk) with amino-pyrimidine derivatives
por: Meenakumari, Krishnamoorthy, et al.
Publicado: (2020)

Role of c-Jun N-Terminal Kinases (JNKs) in Epilepsy and Metabolic Cognitive Impairment
por: Busquets, Oriol, et al.
Publicado: (2019)

Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes
por: Yung, Justin Hou Ming, et al.
Publicado: (2020)

On the effect of hippocampal c-Jun N-terminal kinase inhibition on object recognition memory
por: Rossato, Janine I., et al.
Publicado: (2022)

Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury
por: Jang, Sehwan, et al.
Publicado: (2015)

A JUN N-terminal kinase inhibitor induces ectodomain shedding of the cancer-associated membrane protease Prss14/epithin via protein kinase CβII
por: Yoon, Joobyoung, et al.
Publicado: (2020)

Effect of a Small Selective Inhibitor of C-Jun N-Terminal Kinase on the Inducible mRNA Expression of Interleukin-6 and Interleukin-18
por: Stanilova, Spaska A., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_gtc86abp9nka7ftv3ts55o33ga