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Prognostic indicators for gastrointestinal stromal tumors: a review
Gastrointestinal stromal tumors (GISTs) are potentially malignancies that can occur anywhere in the digestive tract. Tyrosine kinase inhibitors (TKIs) such as imatinib have proven effective since the discovery of KIT and PDGFRA. The current version of NCNN, ESMO and EURACAN guidelines recognized tha...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Neoplasia Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327422/ https://www.ncbi.nlm.nih.gov/pubmed/32619820 http://dx.doi.org/10.1016/j.tranon.2020.100812 |
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author | Zhang, Haixin Liu, Qi |
author_facet | Zhang, Haixin Liu, Qi |
author_sort | Zhang, Haixin |
collection | PubMed |
description | Gastrointestinal stromal tumors (GISTs) are potentially malignancies that can occur anywhere in the digestive tract. Tyrosine kinase inhibitors (TKIs) such as imatinib have proven effective since the discovery of KIT and PDGFRA. The current version of NCNN, ESMO and EURACAN guidelines recognized that the three main prognostic factors are the mitotic rate, tumor size and tumor site. In addition, tumor rupture is also recognized as an independent risk factor. However, recent evidence shows that various types of gene mutations are associated with prognosis, and influencing factors such as gastrointestinal bleeding and high Ki67 index have been associated with poor prognosis. It shows that the current risk classification is still insufficient and controversial. With the emergence of more and more lack mutation in KIT/PDGFRA GISTs (KIT/PDGFRA wild-type GISTs) or drug resistance genes, primary and secondary drug resistance problems are caused, which makes the treatment of late or metastatic GIST face challenges. Therefore, this article will review the clinicopathological characteristics of GIST, the special molecular subtypes and other factors that may affect prognosis. We will also explore reliable prognostic markers for better postoperative management and improve the prognosis of patients with GIST. |
format | Online Article Text |
id | pubmed-7327422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Neoplasia Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-73274222020-07-06 Prognostic indicators for gastrointestinal stromal tumors: a review Zhang, Haixin Liu, Qi Transl Oncol Review article Gastrointestinal stromal tumors (GISTs) are potentially malignancies that can occur anywhere in the digestive tract. Tyrosine kinase inhibitors (TKIs) such as imatinib have proven effective since the discovery of KIT and PDGFRA. The current version of NCNN, ESMO and EURACAN guidelines recognized that the three main prognostic factors are the mitotic rate, tumor size and tumor site. In addition, tumor rupture is also recognized as an independent risk factor. However, recent evidence shows that various types of gene mutations are associated with prognosis, and influencing factors such as gastrointestinal bleeding and high Ki67 index have been associated with poor prognosis. It shows that the current risk classification is still insufficient and controversial. With the emergence of more and more lack mutation in KIT/PDGFRA GISTs (KIT/PDGFRA wild-type GISTs) or drug resistance genes, primary and secondary drug resistance problems are caused, which makes the treatment of late or metastatic GIST face challenges. Therefore, this article will review the clinicopathological characteristics of GIST, the special molecular subtypes and other factors that may affect prognosis. We will also explore reliable prognostic markers for better postoperative management and improve the prognosis of patients with GIST. Neoplasia Press 2020-06-28 /pmc/articles/PMC7327422/ /pubmed/32619820 http://dx.doi.org/10.1016/j.tranon.2020.100812 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review article Zhang, Haixin Liu, Qi Prognostic indicators for gastrointestinal stromal tumors: a review |
title | Prognostic indicators for gastrointestinal stromal tumors: a review |
title_full | Prognostic indicators for gastrointestinal stromal tumors: a review |
title_fullStr | Prognostic indicators for gastrointestinal stromal tumors: a review |
title_full_unstemmed | Prognostic indicators for gastrointestinal stromal tumors: a review |
title_short | Prognostic indicators for gastrointestinal stromal tumors: a review |
title_sort | prognostic indicators for gastrointestinal stromal tumors: a review |
topic | Review article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327422/ https://www.ncbi.nlm.nih.gov/pubmed/32619820 http://dx.doi.org/10.1016/j.tranon.2020.100812 |
work_keys_str_mv | AT zhanghaixin prognosticindicatorsforgastrointestinalstromaltumorsareview AT liuqi prognosticindicatorsforgastrointestinalstromaltumorsareview |