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RNAWRE: a resource of writers, readers and erasers of RNA modifications

RNA modifications are involved in various kinds of cellular biological processes. Accumulated evidences have demonstrated that the functions of RNA modifications are determined by the effectors that can catalyze, recognize and remove RNA modifications. They are called ‘writers’, ‘readers’ and ‘erase...

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Detalles Bibliográficos
Autores principales: Nie, Fulei, Feng, Pengmian, Song, Xiaoming, Wu, Meng, Tang, Qiang, Chen, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327530/
https://www.ncbi.nlm.nih.gov/pubmed/32608478
http://dx.doi.org/10.1093/database/baaa049
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author Nie, Fulei
Feng, Pengmian
Song, Xiaoming
Wu, Meng
Tang, Qiang
Chen, Wei
author_facet Nie, Fulei
Feng, Pengmian
Song, Xiaoming
Wu, Meng
Tang, Qiang
Chen, Wei
author_sort Nie, Fulei
collection PubMed
description RNA modifications are involved in various kinds of cellular biological processes. Accumulated evidences have demonstrated that the functions of RNA modifications are determined by the effectors that can catalyze, recognize and remove RNA modifications. They are called ‘writers’, ‘readers’ and ‘erasers’. The identification of RNA modification effectors will be helpful for understanding the regulatory mechanisms and biological functions of RNA modifications. In this work, we developed a database called RNAWRE that specially deposits RNA modification effectors. The current version of RNAWRE stored 2045 manually curated writers, readers and erasers for the six major kinds of RNA modifications, namely Cap, m(1)A, m(6)A, m(5)C, ψ and Poly A. The main modules of RNAWRE not only allow browsing and downloading the RNA modification effectors but also support the BLAST search of the potential RNA modification effectors in other species. We hope that RNAWRE will be helpful for the researches on RNA modifications. Database URL: http://rnawre.bio2db.com
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spelling pubmed-73275302020-07-15 RNAWRE: a resource of writers, readers and erasers of RNA modifications Nie, Fulei Feng, Pengmian Song, Xiaoming Wu, Meng Tang, Qiang Chen, Wei Database (Oxford) Database Tool RNA modifications are involved in various kinds of cellular biological processes. Accumulated evidences have demonstrated that the functions of RNA modifications are determined by the effectors that can catalyze, recognize and remove RNA modifications. They are called ‘writers’, ‘readers’ and ‘erasers’. The identification of RNA modification effectors will be helpful for understanding the regulatory mechanisms and biological functions of RNA modifications. In this work, we developed a database called RNAWRE that specially deposits RNA modification effectors. The current version of RNAWRE stored 2045 manually curated writers, readers and erasers for the six major kinds of RNA modifications, namely Cap, m(1)A, m(6)A, m(5)C, ψ and Poly A. The main modules of RNAWRE not only allow browsing and downloading the RNA modification effectors but also support the BLAST search of the potential RNA modification effectors in other species. We hope that RNAWRE will be helpful for the researches on RNA modifications. Database URL: http://rnawre.bio2db.com Oxford University Press 2020-07-01 /pmc/articles/PMC7327530/ /pubmed/32608478 http://dx.doi.org/10.1093/database/baaa049 Text en © The Author(s) 2020. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Database Tool
Nie, Fulei
Feng, Pengmian
Song, Xiaoming
Wu, Meng
Tang, Qiang
Chen, Wei
RNAWRE: a resource of writers, readers and erasers of RNA modifications
title RNAWRE: a resource of writers, readers and erasers of RNA modifications
title_full RNAWRE: a resource of writers, readers and erasers of RNA modifications
title_fullStr RNAWRE: a resource of writers, readers and erasers of RNA modifications
title_full_unstemmed RNAWRE: a resource of writers, readers and erasers of RNA modifications
title_short RNAWRE: a resource of writers, readers and erasers of RNA modifications
title_sort rnawre: a resource of writers, readers and erasers of rna modifications
topic Database Tool
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327530/
https://www.ncbi.nlm.nih.gov/pubmed/32608478
http://dx.doi.org/10.1093/database/baaa049
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